Maternal pregestational diabetes and risk of acute lymphoblastic leukemia in the offspring: A population-based study in Northern Italy.
Acute lymphoblastic leukemia
Childhood cancers
Pregestational diabetes
Risk factors
Journal
Cancer epidemiology
ISSN: 1877-783X
Titre abrégé: Cancer Epidemiol
Pays: Netherlands
ID NLM: 101508793
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
05
2019
revised:
09
07
2019
accepted:
14
07
2019
pubmed:
25
7
2019
medline:
31
3
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
This population-based study aims to evaluate the association between maternal pregestational diabetes and risk of acute lymphoblastic leukemia (ALL) in the offspring. All 241,958 children born in three Northern Italy provinces 1998-2010 were followed from birth until first cancer diagnosis (National Childhood Cancer Register), age 15 years, or 31 December 2017. We computed hazard ratio (HR) and 95% CI of ALL in relation to the presence of maternal diabetes through Cox proportional regression models. We observed 145 cases of ALL, with a higher incidence in children born to women with pregestational diabetes compared to the others (12.4 vs 4.6). Adjusted hazard ratio of ALL was 2.6 (CI, 0.6-10.5) for maternal diabetes. We estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Identifiants
pubmed: 31336345
pii: S1877-7821(19)30081-5
doi: 10.1016/j.canep.2019.101572
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101572Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.