Augmentation of IL-6 production contributes to development of gestational diabetes mellitus: An Indian study.
CRP
Gestational diabetes mellitus
IL-6
Inflammation
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Historique:
received:
28
11
2018
accepted:
26
12
2018
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
28
12
2019
Statut:
ppublish
Résumé
Inflammatory mediators like interleukin-6 (IL-6) and acute phase protein like C-reactive protein (CRP) are supposed to contribute to development of GDM, however clinical data supporting this hypothesis is limited. This study was designed to analyze the association of IL-6 and CRP with development of GDM in Indian females. This case control study included pregnant women diagnosed as GDM (n = 53) and those having normal glucose tolerance (n = 50). Serum levels of IL-6 and CRP were analysed and correlated with various clinical parameters. Serum IL-6 levels were significantly high (p < 0.05) in GDM females as compared to control females. IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Unlike IL-6, CRP levels did not show significant differences between GDM and control females. However, positive correlation of CRP levels with BMI, FBS and PPBS was observed. High IL-6 levels in gestational diabetes may indicate a possible role for inflammation in pathophysiology of GDM.
Identifiants
pubmed: 31336542
pii: S1871-4021(18)30583-6
doi: 10.1016/j.dsx.2018.12.023
pii:
doi:
Substances chimiques
Biomarkers
0
IL6 protein, human
0
Interleukin-6
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-899Informations de copyright
Copyright © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.