Cerebrovascular and Neurological Disorders: Protective Role of NRF2.
NRF2
alternative
cerebrovascular
neurodegenerative
oxidative stress
pathway
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Jul 2019
12 Jul 2019
Historique:
received:
13
06
2019
revised:
05
07
2019
accepted:
06
07
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Cellular defense mechanisms, intracellular signaling, and physiological functions are regulated by electrophiles and reactive oxygen species (ROS). Recent works strongly considered imbalanced ROS and electrophile overabundance as the leading cause of cellular and tissue damage, whereas oxidative stress (OS) plays a crucial role for the onset and progression of major cerebrovascular and neurodegenerative pathologies. These include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke, and aging. Nuclear factor erythroid 2-related factor (NRF2) is the major modulator of the xenobiotic-activated receptor (XAR) and is accountable for activating the antioxidative response elements (ARE)-pathway modulating the detoxification and antioxidative responses of the cells. NRF2 activity, however, is also implicated in carcinogenesis protection, stem cells regulation, anti-inflammation, anti-aging, and so forth. Herein, we briefly describe the NRF2-ARE pathway and provide a review analysis of its functioning and system integration as well as its role in major CNS disorders. We also discuss NRF2-based therapeutic approaches for the treatment of neurodegenerative and cerebrovascular disorders.
Identifiants
pubmed: 31336872
pii: ijms20143433
doi: 10.3390/ijms20143433
pmc: PMC6678730
pii:
doi:
Substances chimiques
Biomarkers
0
NF-E2-Related Factor 2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA029121
Pays : United States
Organisme : NIDA NIH HHS
ID : 2R01-DA029121
Pays : United States
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