Uptake of Cervical Cancer Screening in Ethiopia by Self-Sampling HPV DNA Compared to Visual Inspection with Acetic Acid: A Cluster Randomized Trial.
Acetic Acid
/ chemistry
Adult
Cervix Uteri
/ chemistry
Cluster Analysis
DNA, Viral
/ analysis
Diagnostic Self Evaluation
Diagnostic Techniques, Obstetrical and Gynecological
Early Detection of Cancer
/ methods
Ethiopia
/ epidemiology
Female
Human Papillomavirus DNA Tests
/ methods
Humans
Mass Screening
/ methods
Middle Aged
Papillomaviridae
/ genetics
Papillomavirus Infections
/ diagnosis
Patient Acceptance of Health Care
/ statistics & numerical data
Patient Participation
/ statistics & numerical data
Physical Examination
/ methods
Specimen Handling
/ methods
Uterine Cervical Neoplasms
/ diagnosis
Vaginal Smears
/ methods
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
16
03
2019
revised:
23
05
2019
accepted:
16
07
2019
pubmed:
25
7
2019
medline:
29
8
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
In Ethiopia, the standard method of cervical cancer screening is using Visual Inspection with Acetic Acid (VIA). Self-collection-based human papillomavirus (HPV) testing is assumed to improve the uptake of screening, especially for hard to reach populations. We investigated whether HPV DNA testing with the self-collection of cervical samples would be associated with increased uptake and adherence to procedures at the population level compared with VIA within defined rural population in Ethiopia. A total of 22 clusters (comprising 2,356 women ages 30-49 years) were randomized in two arms. Following the community mobilization, women of the clusters were invited to go either to the local health post for a self-collection-based HPV DNA testing (arm A) or Butajira Hospital for VIA screening (arm B). In the HPV arm, of the 1,213 sensitized women, 1,020 (84.1%) accessed the health post for self-sampling compared with the VIA arm, where 575 of 1,143 (50.5%) visited the hospital for VIA (
Identifiants
pubmed: 31337647
pii: 1940-6207.CAPR-19-0156
doi: 10.1158/1940-6207.CAPR-19-0156
doi:
Substances chimiques
DNA, Viral
0
Acetic Acid
Q40Q9N063P
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
609-616Informations de copyright
©2019 American Association for Cancer Research.