Tissue-Resident Macrophages Promote Renal Cystic Disease.
CSF1R
cilia
cystic kidney
macrophages
renal injury
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
09
08
2018
accepted:
26
05
2019
pubmed:
25
7
2019
medline:
29
5
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Mutations affecting cilia proteins have an established role in renal cyst formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction occurs and whether the kidney has been injured. Disruption of cilia function before postnatal day 12-14 results in rapid cyst formation; however, cyst formation is slower when cilia dysfunction is induced after postnatal day 14. Rapid cyst formation can also be induced in conditional adult cilia mutant mice by introducing renal injury. Previous studies indicate that macrophages are involved in cyst formation, however the specific role and type of macrophages responsible has not been clarified. We analyzed resident macrophage number and subtypes during postnatal renal maturation and after renal injury in control and conditional Our data show that renal resident macrophages undergo a phenotypic switch from R2b (CD11c These data uncover an important pathogenic role for resident macrophages during rapid cyst progression.
Sections du résumé
BACKGROUND
Mutations affecting cilia proteins have an established role in renal cyst formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction occurs and whether the kidney has been injured. Disruption of cilia function before postnatal day 12-14 results in rapid cyst formation; however, cyst formation is slower when cilia dysfunction is induced after postnatal day 14. Rapid cyst formation can also be induced in conditional adult cilia mutant mice by introducing renal injury. Previous studies indicate that macrophages are involved in cyst formation, however the specific role and type of macrophages responsible has not been clarified.
METHODS
We analyzed resident macrophage number and subtypes during postnatal renal maturation and after renal injury in control and conditional
RESULTS
Our data show that renal resident macrophages undergo a phenotypic switch from R2b (CD11c
CONCLUSIONS
These data uncover an important pathogenic role for resident macrophages during rapid cyst progression.
Identifiants
pubmed: 31337691
pii: ASN.2018080810
doi: 10.1681/ASN.2018080810
pmc: PMC6779366
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1856Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007051
Pays : United States
Organisme : BLRD VA
ID : I01 BX002298
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK074038
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118932
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK115169
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS057563
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079337
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR048311
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115752
Pays : United States
Informations de copyright
Copyright © 2019 by the American Society of Nephrology.
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