Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity.
Animals
Anthracenes
Antioxidants
/ metabolism
Apoptosis
Cell Line
Cell Survival
Diabetes Mellitus, Type 2
/ metabolism
Enzyme Inhibitors
/ pharmacology
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Fatty Acids
/ chemistry
Glucose
/ metabolism
Homeodomain Proteins
/ metabolism
Insulin-Secreting Cells
/ drug effects
Insulinoma
/ metabolism
Lipids
/ chemistry
MAP Kinase Signaling System
Male
Mice
Mice, Inbred C57BL
Nitric Oxide
/ metabolism
Perylene
/ analogs & derivatives
Rats
Trans-Activators
/ metabolism
Hypericin
apoptosis
diabetes
β-cell protection
Journal
International journal of biological sciences
ISSN: 1449-2288
Titre abrégé: Int J Biol Sci
Pays: Australia
ID NLM: 101235568
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
02
2019
accepted:
30
04
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
17
4
2020
Statut:
epublish
Résumé
A decrease in islet β-cell mass is closely associated with the development and progression of diabetes. Therefore, protection against β-cell loss is an essential measure to prevent and treat diabetes. In this study, we investigated the protective effects of non-photoactivated hypericin, a natural compound, on β-cells both
Identifiants
pubmed: 31337977
doi: 10.7150/ijbs.33817
pii: ijbsv15p1472
pmc: PMC6643136
doi:
Substances chimiques
Anthracenes
0
Antioxidants
0
Enzyme Inhibitors
0
Fatty Acids
0
Homeodomain Proteins
0
Lipids
0
Trans-Activators
0
pancreatic and duodenal homeobox 1 protein
0
Nitric Oxide
31C4KY9ESH
Perylene
5QD5427UN7
hypericin
7V2F1075HD
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1472-1487Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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