Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure.
Antibodies, Monoclonal
Antibodies, Neutralizing
/ immunology
Cell Line
Epitopes
/ immunology
HEK293 Cells
HIV Antibodies
/ immunology
HIV Envelope Protein gp120
/ immunology
HIV Envelope Protein gp41
/ immunology
HIV Infections
/ immunology
HIV Seropositivity
/ immunology
HIV-1
/ immunology
Humans
Virion
/ immunology
FRET-FCS
epitope exposure
neutralizing and non-neutralizing epitopes
single HIV-1 virion
two-color coincidence fluorescence correlation spectroscopy (FCS)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
03
2019
accepted:
17
06
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The trimeric envelope spikes on the HIV-1 virus surface initiate infection and comprise key targets for antiviral humoral responses. Circulating virions variably present intact envelope spikes, which react with neutralizing antibodies; and altered envelope structures, which bind non-neutralizing antibodies. Once bound, either type of antibody can enable humoral effector mechanisms with the potential to control HIV-1 infection
Identifiants
pubmed: 31338095
doi: 10.3389/fimmu.2019.01512
pmc: PMC6628914
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Epitopes
0
HIV Antibodies
0
HIV Envelope Protein gp120
0
HIV Envelope Protein gp41
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1512Subventions
Organisme : NIAID NIH HHS
ID : P01 AI120756
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI124912
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117836
Pays : United States
Références
J Virol. 2001 Mar;75(6):2993-3000
pubmed: 11222724
Biochemistry. 2002 Jan 22;41(3):697-705
pubmed: 11790090
Nature. 2002 Oct 17;419(6908):743-7
pubmed: 12384704
AIDS. 2002 Dec 6;16(18):2409-17
pubmed: 12461414
J Virol. 2003 Jan;77(1):353-65
pubmed: 12477840
J Virol. 2003 Jan;77(2):1084-91
pubmed: 12502824
Nature. 2003 Mar 20;422(6929):307-12
pubmed: 12646921
J Virol. 2003 May;77(10):5678-84
pubmed: 12719560
Science. 2003 Jun 27;300(5628):2065-71
pubmed: 12829775
Protein Sci. 1992 May;1(5):563-74
pubmed: 1304355
J Virol. 1992 Feb;66(2):848-56
pubmed: 1370558
J Med Primatol. 1992 Feb-May;21(2-3):50-8
pubmed: 1433267
AIDS Res Hum Retroviruses. 2005 Feb;21(2):171-89
pubmed: 15725757
Virology. 2005 Jul 20;338(1):154-72
pubmed: 15932765
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13372-7
pubmed: 16174734
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):14943-8
pubmed: 16219699
J Virol. 2006 Feb;80(3):1414-26
pubmed: 16415019
Nat Methods. 2006 Feb;3(2):83-9
pubmed: 16432516
J Virol. 2006 Mar;80(5):2515-28
pubmed: 16474158
FASEB J. 2006 Sep;20(11):1762-74
pubmed: 16940148
J Virol. 2006 Dec;80(23):11776-90
pubmed: 16971434
J Immunol. 1990 Nov 15;145(10):3276-82
pubmed: 1700004
J Virol. 1991 Sep;65(9):4832-8
pubmed: 1714520
Curr HIV Res. 2007 Nov;5(6):561-71
pubmed: 18045112
Nature. 1991 Oct 3;353(6343):393
pubmed: 1815549
Nature. 2008 Sep 4;455(7209):109-13
pubmed: 18668044
PLoS Pathog. 2009 May;5(5):e1000433
pubmed: 19436712
Science. 2009 Oct 9;326(5950):285-9
pubmed: 19729618
Lancet. 1990 Dec 22-29;336(8730):1538-41
pubmed: 1979369
Virology. 2010 Mar 15;398(2):224-32
pubmed: 20060554
J Virol. 2010 Apr;84(7):3382-95
pubmed: 20089658
PLoS Pathog. 2010 May 13;6(5):e1000890
pubmed: 20485520
Clin Vaccine Immunol. 2010 Aug;17(8):1244-51
pubmed: 20534793
Science. 2010 Aug 13;329(5993):811-7
pubmed: 20616231
J Biol Chem. 2011 May 27;286(21):18878-89
pubmed: 21454482
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11181-6
pubmed: 21690411
Nature. 2011 Nov 23;480(7377):336-43
pubmed: 22113616
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5
pubmed: 23100539
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20419-24
pubmed: 23185020
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E69-78
pubmed: 23237851
J Biol Chem. 1990 Jun 25;265(18):10373-82
pubmed: 2355006
J Virol. 2014 Feb;88(3):1795-808
pubmed: 24284318
Science. 1986 Dec 12;234(4782):1392-5
pubmed: 2431482
Proc Natl Acad Sci U S A. 1988 May;85(9):3198-202
pubmed: 2452447
PLoS One. 2014 Feb 14;9(2):e88735
pubmed: 24551145
J Virol. 2014 May;88(9):5165-70
pubmed: 24554654
J Immunol. 2014 Sep 15;193(6):3113-25
pubmed: 25135832
J Immunol. 2014 Sep 15;193(6):3126-33
pubmed: 25143442
Vaccine. 2015 Jan 3;33(2):388-95
pubmed: 25444812
PLoS Pathog. 2015 Mar 25;11(3):e1004772
pubmed: 25807494
J Virol. 2015 Sep;89(17):8840-54
pubmed: 26085162
PLoS Pathog. 2015 Aug 03;11(8):e1005042
pubmed: 26237403
Retrovirology. 2015 Sep 24;12:81
pubmed: 26399966
Science. 2016 Mar 4;351(6277):1043-8
pubmed: 26941313
Sci Rep. 2016 Nov 09;6:36685
pubmed: 27827447
Sci Rep. 2017 Apr 19;7(1):948
pubmed: 28424455
Elife. 2017 May 26;6:
pubmed: 28548638
Cell. 2017 Aug 10;170(4):637-648.e10
pubmed: 28757252
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9893-E9902
pubmed: 29087304
Cell. 2018 Jun 14;173(7):1783-1795.e14
pubmed: 29731169
Proc Natl Acad Sci U S A. 1985 Jul;82(14):4813-7
pubmed: 2991896
Vaccines (Basel). 2018 Jun 29;6(3):null
pubmed: 29966222
Cell Host Microbe. 2018 Aug 8;24(2):221-233.e5
pubmed: 30092199
Cell. 2018 Aug 9;174(4):938-952.e13
pubmed: 30096313
Nat Immunol. 2018 Nov;19(11):1179-1188
pubmed: 30333615
Nat Immunol. 2018 Nov;19(11):1169-1178
pubmed: 30333617
Immunity. 2019 Jan 15;50(1):241-252.e6
pubmed: 30552025
J Virol. 2019 Mar 5;93(6):
pubmed: 30626682
Nature. 1988 Aug 4;334(6181):440-4
pubmed: 3405290
Science. 1994 Nov 11;266(5187):1024-7
pubmed: 7973652
Curr Opin Immunol. 1996 Aug;8(4):540-5
pubmed: 8794008
Biophys J. 1997 Apr;72(4):1878-86
pubmed: 9083691
J Virol. 1998 Jun;72(6):4694-703
pubmed: 9573233
Nature. 1998 Jun 18;393(6686):648-59
pubmed: 9641677
Nature. 1998 Jun 18;393(6686):705-11
pubmed: 9641684
J Virol. 1998 Oct;72(10):7992-8001
pubmed: 9733838
AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1271-80
pubmed: 9764911