Incompatible intravenous drug combinations and respective physician and nurse knowledge: a study in routine paediatric intensive care.

Cefotaxime Drug Incompatibility Intravenous Drug Administration Paediatric Intensive Care Pantoprazole Patient Safety Prescription Vancomycin

Journal

European journal of hospital pharmacy : science and practice
ISSN: 2047-9956
Titre abrégé: Eur J Hosp Pharm
Pays: England
ID NLM: 101578294

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 02 03 2017
revised: 26 05 2017
accepted: 05 06 2017
entrez: 25 7 2019
pubmed: 25 7 2019
medline: 25 7 2019
Statut: ppublish

Résumé

To identify incompatible intravenous drug combinations in routine paediatric intensive care and evaluate physician and nurse knowledge. In a university paediatric intensive care unit, intravenous drug incompatibilities were analysed using a database and physician and nurse knowledge of incompatibilities was assessed using a questionnaire. We analysed 665 prescriptions in 87 patients. Incompatible drug administration was identified in 9 (10%) of the 87 patients with a median of 3 different incompatibilities per patient (Q25/Q75: 1/3). We found 26 incompatible combinations. The most frequently involved drugs were cefotaxime, pantoprazole and vancomycin. A median of 10 of the 15 drug combinations were correctly assessed as compatible or incompatible (Q25/Q75: 8/11). Pantoprazole had a low number (20%) of correct answers. One in 10 patients in paediatric intensive care was affected by drug incompatibility, with knowledge deficits seen in a third of assessed combinations. This indicates quality improvement strategies should be urgently implemented by pharmacists.

Identifiants

pubmed: 31338170
doi: 10.1136/ejhpharm-2017-001248
pii: ejhpharm-2017-001248
pmc: PMC6614696
doi:

Types de publication

Journal Article

Langues

eng

Pagination

214-217

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Martina P Neininger (MP)

Department of Clinical Pharmacy and Drug Safety Center, Leipzig University, Leipzig, Germany.

Patricia Buchholz (P)

Department of Clinical Pharmacy and Drug Safety Center, Leipzig University, Leipzig, Germany.
Pharmacy Department of the University Hospital Leipzig and Drug Safety Center, Leipzig University, Leipzig, Germany.

Roberto Frontini (R)

Department of Clinical Pharmacy and Drug Safety Center, Leipzig University, Leipzig, Germany.
Pharmacy Department of the University Hospital Leipzig and Drug Safety Center, Leipzig University, Leipzig, Germany.

Wieland Kiess (W)

Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany.

Werner Siekmeyer (W)

Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany.

Astrid Bertsche (A)

Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany.

Manuaela Siekmeyer (M)

Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany.

Thilo Bertsche (T)

Department of Clinical Pharmacy and Drug Safety Center, Leipzig University, Leipzig, Germany.

Classifications MeSH