A carbohydrate-reduced high-protein diet improves HbA
Adipose Tissue
/ metabolism
Aged
Anthropometry
Blood Glucose
/ metabolism
Blood Pressure
Body Weight
Cardiovascular Diseases
/ metabolism
Cross-Over Studies
Diabetes Mellitus, Type 2
/ diet therapy
Diet, Carbohydrate-Restricted
Diet, High-Protein
Fatty Liver
Female
Glycated Hemoglobin
/ analysis
Humans
Liver
/ metabolism
Magnetic Resonance Imaging
Male
Middle Aged
Postprandial Period
Treatment Outcome
Carbohydrate restriction
Cardiovascular disease
Dietary intervention
Ectopic fat deposition
Glycaemic control
Metabolism
Non-alcoholic fatty liver disease
Nutritional therapy
Type 2 diabetes mellitus
Weight stability
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
14
02
2019
accepted:
17
06
2019
pubmed:
25
7
2019
medline:
10
7
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Dietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in carbohydrate content is acknowledged. We compared a carbohydrate-reduced high-protein (CRHP) diet with an iso-energetic conventional diabetes (CD) diet to elucidate the effects on glycaemic control and selected cardiovascular risk markers during 6 weeks of full food provision of each diet. The primary outcome of the study was change in HbA Twenty-eight participants completed the study. Fourteen participants carried out 6 weeks of the CRHP intervention followed by 6 weeks of the CD intervention, and 14 participants received the dietary interventions in the reverse order. Compared with a CD diet, a CRHP diet reduced the primary outcome of HbA A moderate macronutrient shift by substituting carbohydrates with protein and fat for 6 weeks reduced HbA ClinicalTrials.gov NCT02764021. The study was funded by grants from Arla Food for Health; the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen; the Department of Clinical Medicine, Aarhus University; the Department of Nutrition, Exercise and Sports, University of Copenhagen; and Copenhagen University Hospital, Bispebjerg.
Identifiants
pubmed: 31338545
doi: 10.1007/s00125-019-4956-4
pii: 10.1007/s00125-019-4956-4
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Banques de données
ClinicalTrials.gov
['NCT02764021']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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