Nonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta-analysis.
gastroesophageal reflux disease
meta-analysis
nonalcoholic fatty liver disease
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
16
12
2018
revised:
07
04
2019
accepted:
19
07
2019
pubmed:
25
7
2019
medline:
2
6
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra-hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta-analysis of relevant studies to examine the association between NAFLD and the risk of GERD. We searched PubMed, Scopus, Embase and Web of Science from 1 January 1975 to 15 December 2018, using predefined terms to identify cross-sectional, case-control and cohort studies investigating the association between NAFLD and GERD. Nine observational studies involving 185 118 subjects were eligible for inclusion in the meta-analysis. Overall, NAFLD was significantly associated with an increased risk of GERD (random effect OR 1.28; 95% CI: 1.12-1.44, I NAFLD is associated with an increased risk of GERD. However, future large and cohort studies are still needed to determine the causal relationship between NAFLD and the risk of GERD.
Sections du résumé
BACKGROUND
BACKGROUND
Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra-hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta-analysis of relevant studies to examine the association between NAFLD and the risk of GERD.
METHODS
METHODS
We searched PubMed, Scopus, Embase and Web of Science from 1 January 1975 to 15 December 2018, using predefined terms to identify cross-sectional, case-control and cohort studies investigating the association between NAFLD and GERD.
RESULTS
RESULTS
Nine observational studies involving 185 118 subjects were eligible for inclusion in the meta-analysis. Overall, NAFLD was significantly associated with an increased risk of GERD (random effect OR 1.28; 95% CI: 1.12-1.44, I
CONCLUSION
CONCLUSIONS
NAFLD is associated with an increased risk of GERD. However, future large and cohort studies are still needed to determine the causal relationship between NAFLD and the risk of GERD.
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13158Subventions
Organisme : Health Commission of Jilin Province, China
ID : 20152019
Informations de copyright
© 2019 Stichting European Society for Clinical Investigation Journal Foundation.
Références
Younossi ZM. Non-alcoholic fatty liver disease-a global public health perspective. J Hepatol. 2019;70(3):531-544.
Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141(4):1249-1253.
Adams LA, Anstee QM, Tilg H, Targher G. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut. 2017;66(6):1138-1153.
Scorletti E, Byrne CD. Extrahepatic diseases and NAFLD: the triangular relationship between NAFLD, Type 2-diabetes and dysbiosis. Dig Dis. 2016;34(Suppl 1):11-18.
Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62(1 Suppl):S47-S64.
Kimura S, Tanaka M. The relationship between non-alcoholic fatty liver disease and reflux esophagitis in Japanese subjects. Gastrointest Endosc. 2007;65(5):AB144.
Lee S, Kim HM, Kim YJ, Moon CM, Cho JH, Han KJ. Erosive esophagitis is associated with fatty liver in school workers. Gastroenterology. 2011;140(5):S-256.
Fujikawa Y, Tominaga K, Fujii H, et al. High prevalence of gastroesophageal reflux symptoms in patients with non-alcoholic fatty liver disease associated with serum levels of triglyceride and cholesterol but not simple visceral obesity. Digestion. 2012;86(3):228-237.
Miele L, Cammarota G, Vero V, et al. Non-alcoholic fatty liver disease is associated with high prevalence of gastro-oesophageal reflux symptoms. Dig Liver Dis. 2012;44(12):1032-1036.
Catanzaro R, Calabrese F, Occhipinti S, et al. Nonalcoholic fatty liver disease increases risk for gastroesophageal reflux symptoms. Dig Dis Sci. 2014;59(8):1939-1945.
Hung W-C, Wu J-S, Yang Y-C, Sun Z-J, Lu F-H, Chang C-J. Nonalcoholic fatty liver disease vs. obesity on the risk of erosive oesophagitis. Eur J Clin Invest. 2014;44(12):1143-1149.
Wijarnpreecha K, Panjawatanan P, Thongprayoon C, Jaruvongvanich V, Ungprasert P. Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: a meta-analysis. Saudi J Gastroenterol. 2017;23(6):311-317.
Yang H-J, Chang Y, Park S-K, et al. Nonalcoholic fatty liver disease is associated with increased risk of reflux esophagitis. Dig Dis Sci. 2017;62(12):3605-3613.
Min YW, Kim Y, Gwak G-Y, et al. Non-alcoholic fatty liver disease and the development of reflux esophagitis: a cohort study. J Gastroenterol Hepatol. 2018;33(5):1053-1058.
Bang KB, Shin JE, Shin HD, Nam KW, Cho YK. Non-obese non-alcoholic fatty liver disease is associted with erosive esophagitis. Gastroenterology. 2018;154(6):S-241.
Fujiwara M, Eguchi Y, Fukumori N, et al. The symptoms of gastroesophageal reflux disease correlate with high body mass index, the aspartate aminotransferase/alanine aminotransferase ratio and insulin resistance in Japanese patients with non-alcoholic fatty liver disease. Intern Med. 2015;54(24):3099-3104.
Simera I, Moher D, Hoey J, Schulz KF, Altman DG. A catalogue of reporting guidelines for health research. Eur J Clin Invest. 2010;40(1):35-53.
Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283(15):2008-2012.
Song JH, Han Y-M, Kim WH, et al. Oxidative stress from reflux esophagitis to esophageal cancer: the alleviation with antioxidants. Free Radical Res. 2016;50(10):1071-1079.
Gargiullo PM, Rothenberg RB, Wilson HG. Confidence intervals, hypothesis tests, and sample sizes for the prevented fraction in cross-sectional studies. Stat Med. 1995;14(1):51-72.
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-1558.
Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures. BMJ. 1997;315(7121):1533-1537.
Chung H, Chon YE, Lee H, et al. Hepatic steatosis is associated with increased risk and severity of erosive esophagitis. Gastroenterology. 2014;146(5):S751-S751.
Yamamoto S, Komori M, Sato M, et al. Features of upper gastrointestinal abnormalities in non-alcoholic steatohepatitis (NASH) patients. Gastroenterology. 2013;144(5):S391-S391.
Hung W-C, Wu J-S, Sun Z-J, Lu F-H, Yang Y-C, Chang C-J. Gender differences in the association of non-alcoholic fatty liver disease and metabolic syndrome with erosive oesophagitis: a cross-sectional study in a Taiwanese population. Bmj Open. 2016;6(11):e013106.
Cheng HH, Chang CS, Wang HJ, Wang WC. Interleukin-1beta and -10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients. J Gastroenterol Hepatol. 2010;25(8):1443-1451.
Rieder F, Biancani P, Harnett K, Yerian L, Falk GW. Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2010;298(5):G571-581.
Mikami DJ, Murayama KM. Physiology and pathogenesis of gastroesophageal reflux disease. Surg Clin North Am. 2015;95(3):515-525.
Polyzos SA, Kountouras J, Polymerou V, Papadimitriou KG, Zavos C, Katsinelos P. Vaspin, resistin, retinol-binding protein-4, interleukin-1alpha and interleukin-6 in patients with nonalcoholic fatty liver disease. Ann Hepatol. 2016;15(5):705-714.
Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease. Metab, Clin Exp. 2016;65(8):1062-1079.
Lee JS, Oh TY, Ahn BO, et al. Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants. Mutat Res. 2001;480-481:189-200.
Oh TY, Lee JS, Ahn BO, et al. Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut. 2001;49(3):364-371.
Inayama M, Hashimoto N, Tokoro T, Shiozaki H. Involvement of oxidative stress in experimentally induced reflux esophagitis and esophageal cancer. Hepatogastroenterology. 2007;54(75):761-765.
Spahis S, Delvin E, Borys JM, Levy E. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxid Redox Signal. 2017;26(10):519-541.
Gokturk S, Akyuz F, Arici S, et al. Gastroesophageal reflux in asymptomatic patients with diabetes: an impedance study diabetes, obesity and gastroesophageal reflux. Exp Clin Endocrinol Diabetes. 2018. https://doi.org/10.1055/a-0783-2327
El-Serag H. The association between obesity and GERD: a review of the epidemiological evidence. Dig Dis Sci. 2008;53(9):2307-2312.
Anand G, Katz PO. Gastroesophageal reflux disease and obesity. Gastroenterol Clin North Am. 2010;39(1):39-46.
Friedenberg FK, Xanthopoulos M, Foster GD, Richter JE. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103(8):2111-2122.
Akyuz F, Uyanikoglu A, Ermis F, et al. Gastroesophageal reflux in asymptomatic obese subjects: an esophageal impedance-pH study. World J Gastroenterol. 2015;21(10):3030-3034.
Chang P, Friedenberg F. Obesity and GERD. Gastroenterol Clin North Am. 2014;43(1):161-173.