Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Adipose Tissue
/ metabolism
Animals
Diabetes Mellitus, Type 2
/ genetics
Genome-Wide Association Study
Glucagon-Like Peptide 1
/ blood
Glucose Tolerance Test
Homeostasis
/ genetics
Insulin
/ blood
Insulin Resistance
/ genetics
Male
Mice
Mice, Knockout
Multidrug Resistance-Associated Proteins
/ metabolism
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
11
02
2019
accepted:
09
04
2019
entrez:
25
7
2019
pubmed:
25
7
2019
medline:
25
4
2020
Statut:
ppublish
Résumé
A previous genome-wide association study linked overexpression of an ATP-binding cassette transporter, ABCC5, in humans with a susceptibility to developing type 2 diabetes with age. Specifically, ABCC5 gene overexpression was shown to be strongly associated with increased visceral fat mass and reduced peripheral insulin sensitivity. Currently, the role of ABCC5 in diabetes and obesity is unknown. This study reports the metabolic phenotyping of a global Abcc5 knockout mouse. A global Abcc5 Abcc5 ABCC5 protein expression levels are inversely related to fat mass and appear to play a role in the regulation of GLP-1 secretion from enteroendocrine cells.
Identifiants
pubmed: 31338999
doi: 10.1002/oby.22521
pmc: PMC6658130
mid: NIHMS1026398
doi:
Substances chimiques
Abcc5 protein, mouse
0
Insulin
0
Multidrug Resistance-Associated Proteins
0
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1292-1304Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P020666/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106263/Z/14/Z
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : UM1 HG006348
Pays : United States
Organisme : Medical Research Council
ID : MR/M009041/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U142661184
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/3
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106262/Z/14/Z
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).
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