Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients.
Aryldialkylphosphatase
/ blood
Biomarkers
/ blood
Blood Pressure
Body Mass Index
Cardiovascular Diseases
/ etiology
Diabetes Mellitus, Type 2
/ complications
Exercise
Female
Follow-Up Studies
Glycated Hemoglobin
/ analysis
Humans
Intra-Abdominal Fat
Male
MicroRNAs
/ blood
Middle Aged
Prospective Studies
Risk Factors
Wearable Electronic Devices
Diabetes mellitus, type 2
Endothelium
Exercise
MicroRNAs
Oxidative stress
Journal
Diabetes & metabolism journal
ISSN: 2233-6087
Titre abrégé: Diabetes Metab J
Pays: Korea (South)
ID NLM: 101556588
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
04
12
2018
accepted:
27
12
2018
pubmed:
25
7
2019
medline:
20
6
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.
Identifiants
pubmed: 31339009
pii: 43.e40
doi: 10.4093/dmj.2018.0254
pmc: PMC6943260
doi:
Substances chimiques
Biomarkers
0
Glycated Hemoglobin A
0
MIRN130 microRNA, human
0
MIRN146 microRNA, human
0
MicroRNAs
0
Aryldialkylphosphatase
EC 3.1.8.1
PON1 protein, human
EC 3.1.8.1
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
893-897Informations de copyright
Copyright © 2019 Korean Diabetes Association.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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