Cardiac autonomic dysfunctions are recovered with vitamin D replacement in apparently healthy individuals with vitamin D deficiency.
cardiac autonomic dysfunction
heart rate variability
vitamin D deficiency
Journal
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
ISSN: 1542-474X
Titre abrégé: Ann Noninvasive Electrocardiol
Pays: United States
ID NLM: 9607443
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
05
2019
revised:
27
05
2019
accepted:
11
06
2019
pubmed:
25
7
2019
medline:
9
9
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Vitamin D (VitD) has important prohormone functions in a wide range of clinical processes. Although it is known that individuals with VitD deficiency have cardiac autonomic dysfunction, there are no convincing data regarding the effect of VitD replacement. We aimed to evaluate the impact of VitD replacement on cardiac autonomic dysfunction. Fifty-two apparently healthy subjects with VitD deficiency and 50 healthy control subjects were enrolled. Prior to VitD replacement, 24-hr Holter recordings were obtained, and HRV parameters were recorded. VitD levels were measured 2 months later after replacement, and control 24-hr Holter recordings were analyzed. The mean age of the patients was 36.04 ± 7.6 years, and 53.9% were female. SDNN (68.58 ± 13.53 vs. 121.02 ± 27.45 ms, p = .001), SDANN (95.96 ± 22.26 vs. 166.48 ± 32.97 ms, p = .001), RMSSD (23 vs. 59 ms, p < .001), and PNN50 (6.5% vs. 36%, p < .001) were significantly lower in patients with VitD deficiency compared with the control group. HRV parameters were improved after VitD replacement [SDNN (68.58 ± 13.53 to 119.87 ± 28.28 ms, p < .001), SDANN (95.96 ± 22.26 to 164.44 ± 33.90 ms, p < .001), RMSSD (23 to 58 ms, p < .001), and PNN50 (6.5 to 33%, p < .001)]. The present study suggested that VitD deficiency was significantly correlated with impaired cardiac autonomic functions assessed by parameters of HRV, and cardiac autonomic dysfunction improved after VitD replacement in otherwise apparently healthy individuals.
Sections du résumé
BACKGROUND
Vitamin D (VitD) has important prohormone functions in a wide range of clinical processes. Although it is known that individuals with VitD deficiency have cardiac autonomic dysfunction, there are no convincing data regarding the effect of VitD replacement. We aimed to evaluate the impact of VitD replacement on cardiac autonomic dysfunction.
METHODS
Fifty-two apparently healthy subjects with VitD deficiency and 50 healthy control subjects were enrolled. Prior to VitD replacement, 24-hr Holter recordings were obtained, and HRV parameters were recorded. VitD levels were measured 2 months later after replacement, and control 24-hr Holter recordings were analyzed.
RESULTS
The mean age of the patients was 36.04 ± 7.6 years, and 53.9% were female. SDNN (68.58 ± 13.53 vs. 121.02 ± 27.45 ms, p = .001), SDANN (95.96 ± 22.26 vs. 166.48 ± 32.97 ms, p = .001), RMSSD (23 vs. 59 ms, p < .001), and PNN50 (6.5% vs. 36%, p < .001) were significantly lower in patients with VitD deficiency compared with the control group. HRV parameters were improved after VitD replacement [SDNN (68.58 ± 13.53 to 119.87 ± 28.28 ms, p < .001), SDANN (95.96 ± 22.26 to 164.44 ± 33.90 ms, p < .001), RMSSD (23 to 58 ms, p < .001), and PNN50 (6.5 to 33%, p < .001)].
CONCLUSION
The present study suggested that VitD deficiency was significantly correlated with impaired cardiac autonomic functions assessed by parameters of HRV, and cardiac autonomic dysfunction improved after VitD replacement in otherwise apparently healthy individuals.
Identifiants
pubmed: 31339201
doi: 10.1111/anec.12677
pmc: PMC6931406
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12677Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Circulation. 1996 Dec 1;94(11):2850-5
pubmed: 8941112
Int J Epidemiol. 1990 Sep;19(3):559-63
pubmed: 2262248
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
pubmed: 21646368
Int J Cardiol. 2014 Mar 15;172(2):506-8
pubmed: 24502876
Endocr Rev. 2005 Aug;26(5):662-87
pubmed: 15798098
N Engl J Med. 2007 Jul 19;357(3):266-81
pubmed: 17634462
J Clin Endocrinol Metab. 2010 Feb;95(2):471-8
pubmed: 20133466
Lancet. 1998 Feb 14;351(9101):478-84
pubmed: 9482439
Circulation. 2000 Sep 12;102(11):1239-44
pubmed: 10982537
Nephron Clin Pract. 2006;102(1):c21-9
pubmed: 16166802
Endokrynol Pol. 2013;64(4):319-27
pubmed: 24002961
Diabetes Care. 2001 Oct;24(10):1793-8
pubmed: 11574444
Ann Noninvasive Electrocardiol. 2005 Jan;10(1):88-101
pubmed: 15649244
Autoimmun Rev. 2012 Dec;12(2):250-9
pubmed: 22564548
Am J Clin Nutr. 2008 Dec;88(6):1519-27
pubmed: 19064511
Hypertension. 2011 Dec;58(6):1021-8
pubmed: 22068871
Ann Noninvasive Electrocardiol. 2019 Nov;24(6):e12677
pubmed: 31339201
Diab Vasc Dis Res. 2015 Sep;12(5):342-51
pubmed: 26150192
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70
pubmed: 25712077
Circ Res. 2014 Jan 17;114(2):379-93
pubmed: 24436433
Arch Intern Med. 2008 Jun 23;168(12):1340-9
pubmed: 18574092
Ann Noninvasive Electrocardiol. 2015 Jul;20(4):378-85
pubmed: 25363566
Am J Physiol. 1982 Dec;243(6):E483-8
pubmed: 7149019
J Am Coll Cardiol. 2008 May 6;51(18):1725-33
pubmed: 18452777