Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia.
Adult
Aged
Animals
Case-Control Studies
Female
Humans
Hypothalamus
/ metabolism
Male
Middle Aged
Neurophysins
/ genetics
Paraventricular Hypothalamic Nucleus
/ metabolism
Protein Precursors
/ genetics
RNA, Messenger
/ metabolism
Radiochemistry
Schizophrenia
/ genetics
Supraoptic Nucleus
/ metabolism
Vasopressins
/ genetics
Young Adult
mRNA
paraventricular
schizophrenia
vasopressin
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
08
01
2019
revised:
30
04
2019
accepted:
01
05
2019
pubmed:
25
7
2019
medline:
15
5
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
This study investigates the expression of mRNA encoding vasopressin in the hypothalamus of autopsy brains of individuals diagnosed with schizophrenia. Ten brains of individuals with schizophrenia and 10 brains from individuals without any disease were examined during autopsy. The hypothalamic block was dissected and immersion fixed in paraformaldehyde, sucrose substituted, frozen, and cut into 20-µm-thick coronal cryostat sections. The sections were hybridized with an S-35-labeled DNA antisense oligo probe and after washing covered by an X-ray film. The hybridization signals on the films were transferred to a computer and densitometrically quantified. The densitometry signals showed a statistically significant lower mRNA expression (53% decrease; p = 0.014) in the paraventricular nucleus of the individuals with schizophrenia compared to the controls. In the supraoptic nucleus, the decrease in the group with schizophrenia was 39% compared to the controls, but this decrease was not statistically significant (p = 0.194). Our results show a low expression of mRNA encoding vasopressin in the paraventricular nucleus of the individuals with schizophrenia. We suggest that vasopressin is not directly involved in the pathogenesis of schizophrenia, but might influence schizophrenic symptoms via vasopressin receptors located in the social behavioral neural network in the forebrain.
Identifiants
pubmed: 31339235
doi: 10.1002/brb3.1355
pmc: PMC6749484
doi:
Substances chimiques
AVP protein, human
0
Neurophysins
0
Protein Precursors
0
RNA, Messenger
0
Vasopressins
11000-17-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01355Informations de copyright
© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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