Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms.
Animals
Antibodies, Monoclonal, Murine-Derived
/ immunology
Cell Line, Tumor
Haptens
/ immunology
Immunoglobulin G
/ immunology
Immunologic Capping
/ immunology
Mast Cells
/ cytology
Mice
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
/ immunology
Rats
Receptors, IgE
/ immunology
Receptors, IgG
/ immunology
SHIP1
degranulation
hapten
mast cell
phosphorylation
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
16
10
2018
revised:
19
06
2019
accepted:
19
07
2019
pubmed:
25
7
2019
medline:
28
5
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Aggregation of IgE bound to high affinity IgE receptor (FcεRI) by multivalent antigen induces mast cell activation. Reportedly, disaggregation of aggregated FcεRI immediately terminated degranulation, and formation of co-ligated FcεRI and low affinity IgG receptor FcγRIIB blocked degranulation by inhibitory signal via SH2-containing inositol 5'-phosphatase 1 (SHIP1) phosphorylation. However, their molecular mechanisms to inhibit mast cell activation have been unclear in detail. Herein, we found that addition of excess monomeric hapten (TNP-alanine) to multivalent antigen (TNP-OVA)-activated rat basophilic leukemia cells and mouse bone marrow-derived mast cells induced immediate and transient Syk dephosphorylation, which was previously phosphorylated by TNP-OVA addition. Syk dephosphorylation correlated to rapidly decreased intracellular Ca
Identifiants
pubmed: 31339552
doi: 10.1002/eji.201847973
doi:
Substances chimiques
Antibodies, Monoclonal, Murine-Derived
0
Fcgr2b protein, mouse
0
Fcgr2b protein, rat
0
Haptens
0
Immunoglobulin G
0
Receptors, IgE
0
Receptors, IgG
0
Inpp5d protein, mouse
EC 3.1.3.86
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
EC 3.1.3.86
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2172-2183Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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