Mesenchymal Stem Cells for Perianal Crohn's Disease.
Crohn’s disease
fistula
perianal
stem cells
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 07 2019
23 07 2019
Historique:
received:
16
06
2019
revised:
14
07
2019
accepted:
17
07
2019
entrez:
26
7
2019
pubmed:
26
7
2019
medline:
25
2
2020
Statut:
epublish
Résumé
Perianal fistulizing Crohn's disease (PFCD) is associated with significant morbidity and might negatively impact the quality of life of CD patients. In the last two decades, the management of PFCD has evolved in terms of the multidisciplinary approach involving gastroenterologists and colorectal surgeons. However, the highest fistula healing rates, even combining surgical and anti-TNF agents, reaches 50% of treated patients. More recently, the administration of mesenchymal stem cells (MSCs) have shown notable promising results in the treatment of PFCD. The aim of this review is to describe the rationale and the possible mechanism of action of MSC application for PFCD and the most recent results of randomized clinical trials. Furthermore, the unmet needs of the current administration process and the expected next steps to improve the outcomes will be addressed.
Identifiants
pubmed: 31340546
pii: cells8070764
doi: 10.3390/cells8070764
pmc: PMC6679174
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Clin Exp Immunol. 2007 Aug;149(2):353-63
pubmed: 17521318
Stem Cells. 2007 Jul;25(7):1737-45
pubmed: 17395768
Inflamm Bowel Dis. 2008 Jan;14(1):29-31
pubmed: 17886289
Cell Stem Cell. 2009 Jul 2;5(1):54-63
pubmed: 19570514
Stem Cell Res Ther. 2017 Jun 6;8(1):136
pubmed: 28583202
Eur J Gastroenterol Hepatol. 2018 Oct;30(10):1148-1154
pubmed: 30095479
Dis Colon Rectum. 2005 Jul;48(7):1416-23
pubmed: 15933795
World J Surg. 1991 Nov-Dec;15(6):763-6; discussion 766-7
pubmed: 1662842
Inflamm Bowel Dis. 2013 Jul;19(8):1772-88
pubmed: 23656897
Immunol Cell Biol. 2013 Jan;91(1):19-26
pubmed: 23090487
Front Biosci (Schol Ed). 2010 Jun 01;2:993-1008
pubmed: 20515838
Gut. 2009 Jul;58(7):929-39
pubmed: 19136511
Gastroenterology. 2018 Apr;154(5):1334-1342.e4
pubmed: 29277560
Gastroenterology. 2015 Oct;149(4):918-27.e6
pubmed: 26116801
Gastroenterology. 2002 Apr;122(4):875-80
pubmed: 11910338
Drugs Today (Barc). 2019 Feb;55(2):95-105
pubmed: 30816884
Blood. 2007 Nov 15;110(10):3499-506
pubmed: 17664353
Circulation. 2005 Jul 12;112(2):214-23
pubmed: 15998673
Nat Cell Biol. 2001 Sep;3(9):778-84
pubmed: 11533656
Gastroenterology. 2017 Jul;153(1):59-62.e2
pubmed: 28400193
Ann Gastroenterol. 2017;30(1):33-44
pubmed: 28042236
Cell Transplant. 2013;22(2):279-85
pubmed: 23006344
Tissue Eng. 2001 Apr;7(2):211-28
pubmed: 11304456
Eur Cell Mater. 2010 Sep 01;20:121-33
pubmed: 21249629
J Cell Physiol. 2006 Jul;208(1):64-76
pubmed: 16557516
Nat Immunol. 2005 Apr;6(4):345-52
pubmed: 15785760
Dis Colon Rectum. 2010 Apr;53(4):486-95
pubmed: 20305451
Eur J Surg. 2000 Mar;166(3):218-22
pubmed: 10755336
Dis Colon Rectum. 1985 Oct;28(10):709-11
pubmed: 4053875
Stem Cells. 2007 Nov;25(11):2739-49
pubmed: 17656645
Gut. 2011 Jun;60(6):788-98
pubmed: 21257987
J Inflamm (Lond). 2005 Jul 26;2:8
pubmed: 16045800
Inflamm Bowel Dis. 2014 Nov;20(11):2022-8
pubmed: 25159455
Stem Cells. 2007 Oct;25(10):2648-59
pubmed: 17615264
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Plast Reconstr Surg. 2002 Jan;109(1):199-209; discussion 210-1
pubmed: 11786812
PLoS One. 2016 Oct 6;11(10):e0164269
pubmed: 27711256
Stem Cell Res Ther. 2018 Jun 19;9(1):168
pubmed: 29921311
Int J Colorectal Dis. 2003 Sep;18(5):451-4
pubmed: 12756590
Gastroenterology. 2011 Sep;141(3):1046-56
pubmed: 21699785
Stem Cell Res Ther. 2015 Jul 24;6:137
pubmed: 26206376
Cell Immunol. 2015 Feb;293(2):113-21
pubmed: 25596473
Gastroenterology. 2009 Mar;136(3):978-89
pubmed: 19135996
Exp Hematol. 2002 Jan;30(1):42-8
pubmed: 11823036
Stem Cells Transl Med. 2013 Jun;2(6):455-63
pubmed: 23694810
Colorectal Dis. 2017 Mar 6;:
pubmed: 28263043
Cell Death Differ. 2014 Feb;21(2):216-25
pubmed: 24185619
Dig Dis Sci. 2013 Dec;58(12):3400-6
pubmed: 24026400
Stem Cells Transl Med. 2015 May;4(5):532-7
pubmed: 25829404
Stem Cells. 2004;22(7):1330-7
pubmed: 15579650
Lancet. 2016 Sep 24;388(10051):1281-90
pubmed: 27477896
Stem Cells. 2013 Nov;31(11):2575-81
pubmed: 23404825
Stem Cells. 2010 Mar 31;28(3):585-96
pubmed: 19967788
Dis Colon Rectum. 2009 Jan;52(1):79-86
pubmed: 19273960
Stem Cell Reports. 2017 Oct 10;9(4):1109-1123
pubmed: 28966116
Stem Cells Dev. 2014 Jul 15;23(14):1611-24
pubmed: 24650034
Mol Ther. 2015 Jul;23(7):1248-1261
pubmed: 25899824
BioDrugs. 2018 Dec;32(6):627-634
pubmed: 30298387
Stem Cells. 2013 Oct;31(10):2231-41
pubmed: 23897677
Annu Rev Biomed Eng. 2010 Aug 15;12:87-117
pubmed: 20415588
Dis Colon Rectum. 2011 Dec;54(12):1465-74
pubmed: 22067173
Arthritis Rheum. 2010 Aug;62(8):2467-75
pubmed: 20506343
Oncogene. 2013 Sep 12;32(37):4343-54
pubmed: 23085755
Gut. 1980 Jun;21(6):525-7
pubmed: 7429313
Dis Colon Rectum. 2018 May;61(5):629-640
pubmed: 29578916
Infect Immun. 2012 Aug;80(8):2632-44
pubmed: 22615241
Stem Cells Int. 2013;2013:130763
pubmed: 24194766
J Neuroimmunol. 2010 Oct 8;227(1-2):185-9
pubmed: 20728948
Curr Stem Cell Res Ther. 2014;9(5):444-50
pubmed: 24853377
Cytotherapy. 2013 Dec;15(12):1527-40
pubmed: 23992827
Blood. 2004 Jun 15;103(12):4619-21
pubmed: 15001472
J Gastrointest Surg. 2018 Nov;22(11):2003-2012
pubmed: 30066070
Nat Rev Immunol. 2008 Sep;8(9):726-36
pubmed: 19172693