The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance.
Animals
Antineoplastic Agents
/ therapeutic use
Cathepsins
/ chemistry
Cell Death
/ drug effects
Cell Line, Tumor
Drug Resistance, Neoplasm
/ genetics
Extracellular Matrix
/ drug effects
Gene Expression Regulation, Neoplastic
Humans
Lymphatic Metastasis
Lysosomes
/ drug effects
Models, Molecular
Neoplasms
/ drug therapy
Neovascularization, Pathologic
/ drug therapy
Protein Conformation
Proto-Oncogene Proteins c-bcl-2
/ genetics
Signal Transduction
cancer progression
cysteine cathepsins
drug resistance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jul 2019
23 Jul 2019
Historique:
received:
26
06
2019
revised:
17
07
2019
accepted:
19
07
2019
entrez:
26
7
2019
pubmed:
26
7
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
Identifiants
pubmed: 31340550
pii: ijms20143602
doi: 10.3390/ijms20143602
pmc: PMC6678516
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Proto-Oncogene Proteins c-bcl-2
0
Cathepsins
EC 3.4.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 16-15-10410
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