Oral antidiabetic medication adherence and glycaemic control among patients with type 2 diabetes mellitus: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia.
Administration, Oral
Adolescent
Adult
Blood Glucose
/ analysis
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ blood
Female
Humans
Hypoglycemic Agents
/ administration & dosage
Male
Medication Adherence
/ statistics & numerical data
Middle Aged
Retrospective Studies
Saudi Arabia
Tertiary Care Centers
Young Adult
adherence
diabetes
electronic health records (EHR)
medication possession ratio (MPR)
oral antidiabetic drugs (OADS)
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
23 07 2019
23 07 2019
Historique:
entrez:
26
7
2019
pubmed:
26
7
2019
medline:
24
7
2020
Statut:
epublish
Résumé
The purpose of this study is to measure the adherence rates of oral antidiabetic drugs (OADs) in patients with type 2 diabetes mellitus (T2DM) and assess the relationship of glycaemic control and adherence to OADs after controlling for other associated factors. Cross-sectional retrospective study. Large tertiary hospital in the central region of Saudi Arabia. 5457patients aged 18 years and older diagnosed with T2DM during the period from 1 January 2016 to 31 December 2016. The modified medication possession ratio (mMPR) was calculated as a proxy measure for adherence of OADs. The factors associated with OADs non-adherence and medication oversupply were assessed using multinomial logistic regression models. The secondary outcomes were to measure the association between OADs adherence and glycaemic control. Majority of patients with T2DM were females (n=3400, 62.3%). The average glycated haemoglobin was 8.2±1.67. Among the study population, 48.6% had good adherence (mMPR >0.8) and 8.6% had a medication oversupply (mMPR >1.2). Good adherence was highest among those using repaglinide (71.0%) followed by pioglitazone (65.0%) and sitagliptin (59.0%). In the multivariate analysis, women with T2DM were more likely to have poor adherence (adjusted OR (AOR)=0.76, 95% CI=0.67, 0.86) compared with men. Also, medication oversupply was more likely among patients with hyperpolypharmacy (AOR=1.88, 95% CI=1.36, 2.63), comorbid osteoarthritis (AOR=1.72, 95% CI=1.20, 02.45) and non-Saudi patients (AOR=1.53, 95% CI=1.16, 2.01). However, no association was found between glycaemic control and adherence to OADs. The study findings support the growing concern of non-adherence to OADs among patients with T2DM in Saudi Arabia. Decision makers have to invest in behavioural interventions that will boost medication adherence rates. This is particularly important in patients with polypharmacy and high burden of comorbid conditions.
Identifiants
pubmed: 31340969
pii: bmjopen-2019-029280
doi: 10.1136/bmjopen-2019-029280
pmc: PMC6661664
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029280Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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