Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
26
04
2019
accepted:
15
06
2019
revised:
03
06
2019
pubmed:
26
7
2019
medline:
21
4
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
New hydroquinone derivatives bearing a vinyl alkyne, pestalotioquinols A and B, were isolated from a fungal culture broth of Pestalotiopsis microspora. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR), and the absolute configuration of the stereogenic center of pestalotioquinol A was assigned using the modified Mosher's method. Nerve growth factor-differentiated neuronal PC12 cells were pretreated with pestalotioquinols A and B and removed from the medium, and then treated with a generator of peroxynitrite (ONOO
Identifiants
pubmed: 31341274
doi: 10.1038/s41429-019-0213-9
pii: 10.1038/s41429-019-0213-9
doi:
Substances chimiques
Hydroquinones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM