Pediatric pulmonary mucormycosis in a diabetic patient treated with extended pleurectomy and Clagett procedure.

Clagett procedure Diabetes Mucormycosis Pediatric thoracic surgery Pneumonectomy Pulmonary mucormycosis

Journal

Journal of pediatric surgery case reports
ISSN: 2213-5766
Titre abrégé: J Pediatr Surg Case Rep
Pays: Netherlands
ID NLM: 101628383

Informations de publication

Date de publication:
Jun 2019
Historique:
entrez: 26 7 2019
pubmed: 26 7 2019
medline: 26 7 2019
Statut: ppublish

Résumé

Mucor is a ubiquitous fungus that is non-pathogenic in healthy people. In immunocompromised hosts, non-functional or absent neutrophils and macrophages result in fungal invasion and infection [1]. Invasive mucor (mucormycosis) most commonly involves the sinuses, brain, or lungs. Pulmonary mucormycosis typically presents in patients with a history of organ transplantation or hematologic malignancy [2], and is rare in patients with diabetes alone. The epidemiology and management of pediatric pulmonary mucormycosis is poorly described. We report an unusual occurrence of this disease, complicated by segmental pulmonary artery thrombus in a 15-year-old with poorly controlled diabetes. His severe, medication-resistant infection was ultimately treated successfully with antifungal medication combined with aggressive surgical debridement. The pulmonary artery segmental thrombus resolved after treatment of the underlying infection without anticoagulation.

Identifiants

pubmed: 31341773
doi: 10.1016/j.epsc.2019.101210
pmc: PMC6655502
mid: NIHMS1528961
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIBIB NIH HHS
ID : R25 EB023856
Pays : United States

Références

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Auteurs

Rebecca C Gologorsky (RC)

Department of Surgery, University of California San Francisco- East Bay, 1411 East 31st Street, Oakland, CA, 94602, USA.

Sora Ely (S)

Department of Surgery, University of California San Francisco- East Bay, 1411 East 31st Street, Oakland, CA, 94602, USA.

Kara A Rothenberg (KA)

Department of Surgery, University of California San Francisco- East Bay, 1411 East 31st Street, Oakland, CA, 94602, USA.

Carol Glaser (C)

Department of Infectious Disease, Kaiser Oakland Medical Center, 3600 Broadway, Oakland, CA 94611, USA.

Jeffrey B Velotta (JB)

Department of Surgery, Kaiser Oakland Medical Center, 3600 Broadway, Oakland, CA 94611, USA.

Classifications MeSH