The role of epigenetic changes in preeclampsia.
Acetylation
Core Binding Factor Alpha 3 Subunit
/ genetics
DNA Methylation
Epigenesis, Genetic
Female
Fetus
Gestational Age
Histones
/ genetics
Humans
MicroRNAs
/ genetics
Placenta
/ metabolism
Placentation
/ genetics
Pre-Eclampsia
/ genetics
Pregnancy
RNA, Long Noncoding
/ genetics
Signal Transduction
DNA methylation
epigenetics
histone modification
microRNA
preeclampsia
Journal
BioFactors (Oxford, England)
ISSN: 1872-8081
Titre abrégé: Biofactors
Pays: Netherlands
ID NLM: 8807441
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
19
04
2019
accepted:
13
06
2019
pubmed:
26
7
2019
medline:
23
2
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
Preeclampsia (PE) is a disorder affecting 2-10% of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be related to different diseases such as PE. Abnormal DNA methylation during placentation is the most important epigenetic factor correlated with PE. Moreover, changes in histone modification like acetylation and also the effect of overregulation or low regulation of miRNAs or long noncoding RNAs on variety signaling pathways can be resulted in PE. The aim of this review is to describe of studies about epigenetic changes in PE and its therapeutic strategies.
Substances chimiques
Core Binding Factor Alpha 3 Subunit
0
Histones
0
MicroRNAs
0
RNA, Long Noncoding
0
Runx3 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
712-724Subventions
Organisme : Tabriz University of Medical Sciences
Informations de copyright
© 2019 International Union of Biochemistry and Molecular Biology.
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