The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
13
12
2018
accepted:
30
06
2019
revised:
06
08
2019
pubmed:
26
7
2019
medline:
24
12
2019
entrez:
26
7
2019
Statut:
epublish
Résumé
The initial interaction between a microbial pathogen and the host immune response influences the outcome of the battle between the host and the foreign invader. Leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, provides a model to study relevant human immune responses. Previous studies have adopted a targeted approach to investigate host response to M. leprae infection, focusing on the induction of specific molecules and pathways. By measuring the host transcriptome triggered by M. leprae infection of human macrophages, we were able to detect a host gene signature 24-48 hours after infection characterized by specific innate immune pathways involving the cell fate mechanisms autophagy and apoptosis. The top upstream regulator in the M. leprae-induced gene signature was NUPR1, which is found in the M. leprae-induced cell fate pathways. The induction of NUPR1 by M. leprae was dependent on the production of the type I interferon (IFN), IFN-β. Furthermore, NUPR1 mRNA and protein were upregulated in the skin lesions from patients with the multibacillary form of leprosy. Together, these data indicate that M. leprae induces a cell fate program which includes NUPR1 as part of the host response in the progressive form of leprosy.
Identifiants
pubmed: 31344041
doi: 10.1371/journal.pntd.0007589
pii: PNTD-D-18-01941
pmc: PMC6684084
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Interferon Type I
0
NUPR1 protein, human
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0007589Subventions
Organisme : NIAID NIH HHS
ID : R01 AI022553
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR040312
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073252
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Oncol Rep. 2018 Sep;40(3):1487-1494
pubmed: 30015974
Sci Rep. 2016 Jun 16;6:27870
pubmed: 27306590
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Cell Host Microbe. 2009 Oct 22;6(4):343-53
pubmed: 19837374
Nature. 2010 Aug 19;466(7309):973-7
pubmed: 20725040
Cell Host Microbe. 2015 Jun 10;17(6):799-810
pubmed: 26048138
J Infect Dis. 2016 Jul 15;214(2):311-20
pubmed: 27190175
Nature. 2004 Feb 12;427(6975):636-40
pubmed: 14737177
Nat Med. 2015 Apr;21(4):401-6
pubmed: 25730264
Cell Death Dis. 2016 Mar 31;7:e2161
pubmed: 27031958
Science. 2006 Mar 24;311(5768):1770-3
pubmed: 16497887
Clin Microbiol Rev. 2006 Apr;19(2):338-81
pubmed: 16614253
Mol Microbiol. 2015 Dec;98(5):910-929
pubmed: 26288377
Cell Microbiol. 2010 Nov;12(11):1648-65
pubmed: 20560977
Autophagy. 2009 Oct;5(7):1048-9
pubmed: 19652543
FEMS Immunol Med Microbiol. 2004 Jul 1;41(3):265-9
pubmed: 15196577
Nature. 2013 Sep 26;501(7468):512-6
pubmed: 24005326
J Neurooncol. 2017 Mar;132(1):15-26
pubmed: 28000106
Crit Rev Oncol Hematol. 2007 Sep;63(3):241-4
pubmed: 17644402
Nucleic Acids Res. 2010 Sep;38(17):e169
pubmed: 20660011
Sci Rep. 2018 Nov 19;8(1):16999
pubmed: 30451898
Science. 2013 Mar 22;339(6126):1448-53
pubmed: 23449998
FEMS Immunol Med Microbiol. 2010 Dec;60(3):270-4
pubmed: 20964723
PLoS Pathog. 2016 Jun 29;12(6):e1005705
pubmed: 27355424
PLoS One. 2009 Jun 05;4(6):e5810
pubmed: 19503839
Sci Transl Med. 2011 Oct 12;3(104):104ra102
pubmed: 21998409
Infect Immun. 2015 Nov;83(11):4277-92
pubmed: 26283340
PLoS Pathog. 2017 Jan 5;13(1):e1006103
pubmed: 28056107
J Invest Dermatol. 2015 Oct;135(10):2410-2417
pubmed: 26030183
Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73
pubmed: 5950347
Nature. 2015 Dec 24;528(7583):565-9
pubmed: 26649827
Nat Commun. 2016 Jul 22;7:12218
pubmed: 27447865
Clin Cancer Res. 2001 May;7(5):1320-4
pubmed: 11350901
J Cell Physiol. 2011 Jun;226(6):1439-43
pubmed: 20658514
Curr Opin Immunol. 2011 Feb;23(1):65-70
pubmed: 21071195
J Immunol. 2007 Aug 15;179(4):2060-3
pubmed: 17675463
Front Immunol. 2018 Mar 09;9:463
pubmed: 29593724
Nat Cell Biol. 2006 Oct;8(10):1124-32
pubmed: 16998475
PLoS Pathog. 2016 Aug 08;12(8):e1005809
pubmed: 27500737
PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004335
pubmed: 26751388
J Med Microbiol. 2005 Mar;54(Pt 3):235-42
pubmed: 15713606
Mol Biol Cell. 2010 Apr 15;21(8):1335-49
pubmed: 20181828
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Sep;33(9):1240-1246
pubmed: 29089084
Autophagy. 2018;14(4):654-670
pubmed: 29130426
IUBMB Life. 2009 Dec;61(12):1153-8
pubmed: 19946894
Genome Res. 2015 May;25(5):679-89
pubmed: 25858952
Clin Cancer Res. 2012 Oct 1;18(19):5234-46
pubmed: 22899799
Science. 1991 Oct 11;254(5029):277-9
pubmed: 1925582
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
J Cell Biochem. 2015 Oct;116(10):2283-92
pubmed: 25833220
Front Mol Neurosci. 2017 Jun 26;10:203
pubmed: 28694771
J Infect Dis. 2017 Sep 15;216(6):776-779
pubmed: 28934421
Cell. 2017 Aug 24;170(5):973-985.e10
pubmed: 28841420
Microbes Infect. 2017 Nov;19(11):505-514
pubmed: 28684130
Future Microbiol. 2011 Jan;6(1):57-71
pubmed: 21162636
Cell Host Microbe. 2009 Sep 17;6(3):231-43
pubmed: 19748465
ILAR J. 2014;54(3):304-14
pubmed: 24615444
Breast Cancer Res. 2010;12(4):R56
pubmed: 20663194
Anticancer Res. 2005 Mar-Apr;25(2A):833-7
pubmed: 15868916
Autophagy. 2015;11(12):2172-83
pubmed: 26565952
Cell Host Microbe. 2015 Jun 10;17(6):820-8
pubmed: 26048137
mBio. 2016 Apr 05;7(2):e00342-16
pubmed: 27048801
Cell Host Microbe. 2015 Jun 10;17(6):811-819
pubmed: 26048136