Safety of menopausal hormone therapy in breast cancer survivors older than fifty at diagnosis: A systematic review and meta-analysis.
Age Factors
Aged
Aged, 80 and over
Breast Neoplasms
/ drug therapy
Cancer Survivors
Case-Control Studies
Disease-Free Survival
Female
Follow-Up Studies
Geriatric Assessment
Hormone Replacement Therapy
/ adverse effects
Humans
Middle Aged
Neoplasm Recurrence, Local
/ chemically induced
Randomized Controlled Trials as Topic
Risk
Survival Analysis
Breast cancer
Hormone replacement therapy
Mortality
Postmenopausal
Recurrence
Survivorship
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
27
01
2019
revised:
02
06
2019
accepted:
07
06
2019
pubmed:
26
7
2019
medline:
6
2
2020
entrez:
26
7
2019
Statut:
ppublish
Résumé
Due to the higher incidence of hormone responsive tumours in women >50, the safety of hormone replacement therapy (HRT) in older breast cancer survivors may differ from younger age groups. The primary outcome in this review was the risk of tumour recurrence and secondary outcome the relationship with breast cancer-related mortality. Medline, CINAHL, Cochrane, Google Scholar and EMBASE databases were searched through August 2018 for studies reporting exposure to HRT in survivors ≥50 at primary diagnosis. Random effects models were used to estimate the combined relative risk (RR) of tumour recurrence and breast cancer-related mortality using the Mantel-Haenszel method and the quality of evidence determined for the primary outcome. Overall, nine studies (four cohort, one case-control, four RCTs; n = 16,002) were included. Very low quality evidence from observational studies demonstrated no adverse effect on tumour recurrence with HRT use (RR 0.80, 95% CI 0.53 to 1.19; I
Identifiants
pubmed: 31344603
pii: S0960-9776(19)30514-4
doi: 10.1016/j.breast.2019.06.002
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-55Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.