Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth.
fibrogenesis
hepatic stellate cells
histopathological growth patterns
metastatic uveal melanoma
quantitative polarization microscopy
xenografts
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jul 2019
24 Jul 2019
Historique:
received:
26
06
2019
revised:
19
07
2019
accepted:
22
07
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
28
7
2019
Statut:
epublish
Résumé
Uveal melanoma (UM) is a malignant intraocular tumor that spreads to the liver in half of the cases. Since hepatic cells could play a role in the therapeutic resistance of metastatic UM, the purpose of our study was to investigate the pro-invasive role of hepatic stellate cells (HSteCs) in metastatic UM at the micro- and macro-metastatic stages. We first performed an immunostaining with the alpha-smooth muscle actin (αSMA) to localize activated HSteCs in UM liver macro-metastases from four patients. Their accumulation of collagen was assessed with Masson's Trichrome stain. Next, we inoculated metastatic UM cells alone or with human HSteCs in triple-immunodeficient mice, in order to determine if HSteCs are recruited as early as the micro-metastatic stage. The growth of metastatic foci was imaged in the liver by
Identifiants
pubmed: 31344830
pii: cancers11081043
doi: 10.3390/cancers11081043
pmc: PMC6721369
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fonds de Recherche du Québec - Santé
ID : NA
Organisme : Canada Foundation for Innovation
ID : 32808
Organisme : Fondation du CHU de Québec
ID : NA
Organisme : Fondation des Maladies de l'Oeil
ID : NA
Organisme : Vision Health Research Network
ID : NA
Organisme : Cancer Research Society
ID : NA
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