SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes.
Animals
Diabetes Mellitus, Experimental
/ drug therapy
Diabetic Retinopathy
/ drug therapy
Disease Models, Animal
Electroretinography
Humans
Inflammation
/ drug therapy
Mice
Ophthalmic Solutions
/ pharmacology
Peptides
/ chemistry
Retina
/ drug effects
Suppressor of Cytokine Signaling 1 Protein
/ chemistry
db/db mouse
diabetic retinopathy
microvascular impairment
neuroinflammation
suppressors of cytokine signaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jul 2019
24 Jul 2019
Historique:
received:
18
06
2019
revised:
18
07
2019
accepted:
22
07
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly affected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the effect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is effective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DR.
Identifiants
pubmed: 31344857
pii: ijms20153615
doi: 10.3390/ijms20153615
pmc: PMC6695852
pii:
doi:
Substances chimiques
Ophthalmic Solutions
0
Peptides
0
Suppressor of Cytokine Signaling 1 Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : PI16/00541, SAF2015-63696-R, PI14/00386, PI17/01495 and DTS-2017/00203
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