Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract.
ambulatory blood pressure monitoring
butyrate
cardiovascular disease
children
chronic kidney disease
congenital anomalies of the kidney and urinary tract (CAKUT)
gut microbiota
hypertension
propionate
short chain fatty acid
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Jul 2019
24 Jul 2019
Historique:
received:
27
06
2019
revised:
14
07
2019
accepted:
19
07
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
28
7
2019
Statut:
epublish
Résumé
Both kidney disease and hypertension can originate from early life. Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of chronic kidney disease (CKD) in children. Since gut microbiota and their metabolite short chain fatty acids (SCFAs) have been linked to CKD and hypertension, we examined whether gut microbial composition and SCFAs are correlated with blood pressure (BP) load and renal outcome in CKD children with CAKUT. We enrolled 78 children with CKD stage G1-G4. Up to 65% of children with CAKUT had BP abnormalities on 24 h ambulatory blood pressure monitoring (ABPM). CKD children with CAKUT had lower risk of developing BP abnormalities and CKD progression than those with non-CAKUT. Reduced plasma level of propionate was found in children with CAKUT, which was related to increased abundance of phylum
Identifiants
pubmed: 31344888
pii: jcm8081090
doi: 10.3390/jcm8081090
pmc: PMC6722976
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Kaohsiung Chang Gung Memorial Hospital, Taiwan
ID : CORPG8F1031, CORPG8F1032, and CORPG8F1033
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