Antitumor action of diphenyl diselenide nanocapsules: In vitro assessments and preclinical evidence in an animal model of glioblastoma multiforme.
Animals
Antineoplastic Agents
/ chemistry
Astrocytes
/ drug effects
Benzene Derivatives
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cells, Cultured
Disease Models, Animal
Drug Screening Assays, Antitumor
Glioblastoma
/ drug therapy
Male
Nanocapsules
/ chemistry
Nitrites
/ analysis
Organoselenium Compounds
/ chemistry
Rats
Rats, Wistar
Cancer
Glioma
Polymeric nanoparticles
Selenium
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
12
03
2019
revised:
09
05
2019
accepted:
14
06
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
19
2
2020
Statut:
ppublish
Résumé
Gliomas are the most aggressive malignant tumors of the central nervous system. The diphenyl diselenide [(PhSe) In this sense, the current study was designed to further evaluate the (PhSe) For the in vitro tests, the cell viability, propidium iodide uptake and nitrite levels of rat glioma C6 cells were determined after incubation with free (PhSe) Both compound forms decreased the C6 glioma cells viability without causing any effect in astrocytes cells (healthy control). Importantly, the NC (PhSe) The (PhSe)
Sections du résumé
BACKGROUND
BACKGROUND
Gliomas are the most aggressive malignant tumors of the central nervous system. The diphenyl diselenide [(PhSe)
OBJECTIVE
OBJECTIVE
In this sense, the current study was designed to further evaluate the (PhSe)
METHODS
METHODS
For the in vitro tests, the cell viability, propidium iodide uptake and nitrite levels of rat glioma C6 cells were determined after incubation with free (PhSe)
MAIN FINDINGS
RESULTS
Both compound forms decreased the C6 glioma cells viability without causing any effect in astrocytes cells (healthy control). Importantly, the NC (PhSe)
PRINCIPAL CONCLUSIONS
CONCLUSIONS
The (PhSe)
Identifiants
pubmed: 31345356
pii: S0946-672X(19)30179-8
doi: 10.1016/j.jtemb.2019.06.010
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzene Derivatives
0
Nanocapsules
0
Nitrites
0
Organoselenium Compounds
0
diphenyldiselenide
1666-13-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-189Informations de copyright
Copyright © 2019 Elsevier GmbH. All rights reserved.