Oral mucositis in head and neck cancer: Evidence-based management and review of clinical trial data.

Antineoplastic Agents / adverse effects Chemoradiotherapy / adverse effects Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Evidence-Based Medicine / methods Head and Neck Neoplasms / therapy Humans Quality of Life Radiation Injuries / complications Severity of Illness Index Stomatitis / complications Treatment Outcome
Chemo-radiation Chemotherapy Head and neck cancer Oral mucositis Radiotherapy

Journal

Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118

Informations de publication

Date de publication:
08 2019
Historique:
received: 21 12 2018
revised: 29 04 2019
accepted: 17 05 2019
entrez: 27 7 2019
pubmed: 28 7 2019
medline: 7 7 2020
Statut: ppublish

Résumé

Oral Mucositis (OM) continues to be an oncologic challenge in the context of antineoplastic therapy for head and neck cancer (HNC) treatment. It is a dose-limiting toxicity of chemotherapy and radiation treatment and negatively impacts quality of life and cancer treatment efficacy. Significant effort in the field of OM has been made to help alleviate its symptoms and its subsequent clinical and economic impact. Despite these advances, the treatment of oral mucositis remains difficult and focuses on palliative measures. There are, however, many promising new biological targets currently undergoing investigation to ameliorate or help prevent the toxicity of OM in HNC. Some of these targets undergoing investigation in phase 2 and 3 clinical trials are further highlighted along with the pathobiology of OM, clinical course, prevention, and management measures.

Identifiants

DOI: 10.1016/j.oraloncology.2019.05.013 PMID: 31345391
pubmed: 31345391
pii: S1368-8375(19)30161-7
doi: 10.1016/j.oraloncology.2019.05.013
pii:
doi:

Substances chimiques

Antineoplastic Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-34

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Adriana Blakaj (A)

Yale School of Medicine, Department of Therapeutic Radiology, 35 Park St., New Haven, CT 06519, USA.

Marcelo Bonomi (M)

The Ohio State University, Division of Medical Oncology, 320 West 10th Avenue, Columbus, OH 43210, USA.

Mauricio E Gamez (ME)

The Ohio State University, Department of Radiation Oncology, 460 West 10th Avenue, Columbus, OH 43210, USA.

Dukagjin M Blakaj (DM)

The Ohio State University, Department of Radiation Oncology, 460 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: Dukagjin.Blakaj@osumc.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Chimioradiothérapie › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques de phase II comme sujet › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques de phase III comme sujet › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine factuelle › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Effets des rayonnements › Lésions radiques › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Stomatite › Oral mucositis in head and neck cancer:...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Oral mucositis in head and neck cancer:...