Efficacy of head and neck computed tomography for skeletal muscle mass estimation in patients with head and neck cancer.
Age Factors
Aged
Body Composition
/ physiology
Cervical Vertebrae
Female
Follow-Up Studies
Head and Neck Neoplasms
/ complications
Humans
Kaplan-Meier Estimate
Lumbar Vertebrae
Male
Middle Aged
Muscle, Skeletal
/ diagnostic imaging
Neoplasm Staging
Predictive Value of Tests
Prognosis
Prospective Studies
ROC Curve
Reference Values
Sarcopenia
/ diagnostic imaging
Sex Factors
Squamous Cell Carcinoma of Head and Neck
/ complications
Tomography, X-Ray Computed
Cross-sectional area
Head and neck computed tomography
Head and neck squamous cell carcinoma
Prediction
Skeletal muscle mass
Survival
Journal
Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
05
04
2019
revised:
21
05
2019
accepted:
07
06
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
7
7
2020
Statut:
ppublish
Résumé
Diminished skeletal muscle mass (SMM) is a reliable marker of poor survival outcomes in patients with cancer. SMM or body composition is generally assessed at the third lumbar vertebra (L3) by abdominal computed tomography (CT) scans, not routinely evaluated in patients with head and neck squamous cell carcinoma (HNSCC). Therefore, we evaluated the effectiveness of head and neck CT images to assess SMM in patients with HNSCC for predicting their overall survival. SMM was assessed in 305 consecutive patients with stage III-IV HNSCC by measuring the cross-sectional area (CSA) at the third lumbar and cervical (C3) vertebrae levels. A formula for predicting the L3 SMM was established using linear regression analysis obtained from C3 CSA and other clinical factors. The actual SMM CSAs measured at L3 level and those obtained from the prediction model were compared using correlation analysis. The predictive power of our formula for estimating overall survival was compared using C-index. Median SMM CSAs at the L3 and C3 levels were 174.5 cm Head and neck CT imaging might be useful to estimate L3 SMM and predict overall survival in HNSCC patients.
Identifiants
pubmed: 31345401
pii: S1368-8375(19)30198-8
doi: 10.1016/j.oraloncology.2019.06.009
pii:
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-99Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.