Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.
AMP-Activated Protein Kinases
/ metabolism
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Forkhead Box Protein O3
/ metabolism
Gene Expression Regulation, Neoplastic
Humans
Neoplasms
/ genetics
Phosphorylation
Signal Transduction
gamma-Glutamylcyclotransferase
/ genetics
p21-Activated Kinases
/ metabolism
AMP-Activated protein kinase
Cancer cell growth inhibition
Forkhead box O transcription factor 3a
Gamma-glutamylcyclotransferase
p21(WAF1/CIP1)
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
17 09 2019
17 09 2019
Historique:
received:
10
07
2019
accepted:
17
07
2019
pubmed:
28
7
2019
medline:
9
6
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Inhibition of gamma-glutamylcyclotransferase (GGCT), which is highly expressed in various cancer tissues, exerts anticancer effects both in vitro and in vivo. Previous studies have shown that depletion of GGCT blocks the growth of MCF7 breast cancer cells via upregulation of the cyclin-dependent kinase inhibitor p21
Identifiants
pubmed: 31345573
pii: S0006-291X(19)31399-3
doi: 10.1016/j.bbrc.2019.07.049
pii:
doi:
Substances chimiques
FOXO3 protein, human
0
Forkhead Box Protein O3
0
p21-Activated Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
gamma-Glutamylcyclotransferase
EC 4.3.2.9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-243Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.