Kinetics of immune cell reconstitution predict survival in allogeneic bone marrow and G-CSF-mobilized stem cell transplantation.


Journal

Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425

Informations de publication

Date de publication:
13 08 2019
Historique:
received: 13 12 2018
accepted: 15 05 2019
entrez: 27 7 2019
pubmed: 28 7 2019
medline: 1 8 2020
Statut: ppublish

Résumé

The clinical utility of monitoring immune reconstitution after allotransplant was evaluated using data from Blood and Marrow Transplant Clinical Trials Network BMT CTN 0201 (NCT00075816), a multicenter randomized study of unrelated donor bone marrow (BM) vs granulocyte colony-stimulating factor (G-CSF)-mobilized blood stem cell (G-PB) grafts. Among 410 patients with posttransplant flow cytometry measurements of immune cell subsets, recipients of G-PB grafts had faster T-cell reconstitution than BM recipients, including more naive CD4

Identifiants

pubmed: 31345792
pii: bloodadvances.2018029892
doi: 10.1182/bloodadvances.2018029892
pmc: PMC6693008
doi:

Substances chimiques

Granulocyte Colony-Stimulating Factor 143011-72-7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2250-2263

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD072245
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL069294
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI145231
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145231
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188523
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG1 HL069301
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States
Organisme : NHLBI NIH HHS
ID : U24 HL138660
Pays : United States

Informations de copyright

© 2019 by The American Society of Hematology.

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Auteurs

Edmund K Waller (EK)

Winship Cancer Institute of Emory University, Atlanta, GA.

Brent R Logan (BR)

Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.

Mingwei Fei (M)

Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.

Stephanie J Lee (SJ)

Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA.

Dennis Confer (D)

National Marrow Donor Program, Minneapolis, MN.

Alan Howard (A)

National Marrow Donor Program, Minneapolis, MN.

Shanmuganathan Chandrakasan (S)

Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA.

Claudio Anasetti (C)

Moffitt Cancer Center, Tampa, FL; and.

Shanelle M Fernando (SM)

Emory College, Emory University, Atlanta, GA.

Cynthia R Giver (CR)

Winship Cancer Institute of Emory University, Atlanta, GA.

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Classifications MeSH