Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
07 10 2019
07 10 2019
Historique:
received:
12
04
2019
revised:
29
05
2019
accepted:
24
06
2019
pubmed:
28
7
2019
medline:
11
6
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Human anti-HIV-1 broadly neutralizing antibodies (bNAbs) protect against infection in animal models. However, bNAbs have not been elicited by vaccination in diverse wild-type animals or humans, in part because B cells expressing the precursors of these antibodies do not recognize most HIV-1 envelopes (Envs). Immunogens have been designed that activate these B cell precursors in vivo, but they also activate competing off-target responses. Here we report on a complementary approach to expand specific B cells using an anti-idiotypic antibody, iv8, that selects for naive human B cells expressing immunoglobulin light chains with 5-amino acid complementarity determining region 3s, a key feature of anti-CD4 binding site (CD4bs)-specific VRC01-class antibodies. In mice, iv8 induced target cells to expand and mature in the context of a polyclonal immune system and produced serologic responses targeting the CD4bs on Env. In summary, the results demonstrate that an anti-idiotypic antibody can specifically recognize and expand rare B cells that express VRC01-class antibodies against HIV-1.
Identifiants
pubmed: 31345931
pii: jem.20190446
doi: 10.1084/jem.20190446
pmc: PMC6780999
doi:
Substances chimiques
Antibodies, Anti-Idiotypic
0
Antibodies, Neutralizing
0
HIV Antibodies
0
HIV Envelope Protein gp160
0
Banques de données
GENBANK
['MK611925', 'MK611928']
PDB
['6MFT']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2316-2330Subventions
Organisme : NIAID NIH HHS
ID : P01 AI138212
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI081625
Pays : United States
Organisme : NIH HHS
ID : S10 OD021832
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109632
Pays : United States
Informations de copyright
© 2019 Dosenovic et al.
Références
Curr Opin Immunol. 2018 Aug;53:209-216
pubmed: 30190230
Cell. 2016 Sep 8;166(6):1471-1484.e18
pubmed: 27610571
Science. 2016 Mar 25;351(6280):1458-63
pubmed: 27013733
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3
pubmed: 15299374
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6049-54
pubmed: 23524883
PLoS Pathog. 2013 Jan;9(1):e1003106
pubmed: 23300456
Science. 2013 May 10;340(6133):711-6
pubmed: 23539181
J Exp Med. 2017 Sep 4;214(9):2573-2590
pubmed: 28847869
J Immunol. 2000 Jul 1;165(1):20-3
pubmed: 10861030
Infect Immun. 2008 Aug;76(8):3817-23
pubmed: 18474650
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9781-6
pubmed: 10449771
Cell. 2015 Jun 18;161(7):1505-15
pubmed: 26091035
Science. 2016 Sep 30;353(6307):1557-1560
pubmed: 27608668
J Exp Med. 2002 May 6;195(9):1215-21
pubmed: 11994427
Immunity. 2007 Aug;27(2):203-13
pubmed: 17707129
J Virol. 2012 Apr;86(8):4688-92
pubmed: 22301150
Cell. 2016 Sep 8;166(6):1459-1470.e11
pubmed: 27610570
Science. 2011 Oct 21;334(6054):373-6
pubmed: 22021856
Immunity. 2015 Nov 17;43(5):959-73
pubmed: 26588781
PLoS One. 2014 Jul 03;9(7):e99881
pubmed: 24992528
Biochem Biophys Res Commun. 2009 Dec 18;390(3):404-9
pubmed: 19748484
Cell. 2013 Mar 28;153(1):126-38
pubmed: 23540694
Sci Transl Med. 2018 Jul 4;10(448):
pubmed: 29973404
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18979-84
pubmed: 20956293
Nature. 2014 Mar 13;507(7491):201-6
pubmed: 24499818
Methods Enzymol. 1997;276:307-26
pubmed: 27754618
Nat Commun. 2017 Nov 23;8(1):1732
pubmed: 29170366
Cell. 2015 Jun 4;161(6):1280-92
pubmed: 26004070
Science. 2011 Aug 12;333(6044):843-50
pubmed: 21737702
J Immunol Methods. 2009 Oct 31;350(1-2):183-93
pubmed: 19716372
J Exp Med. 2013 Feb 11;210(2):209-23
pubmed: 23401570
Nat Struct Mol Biol. 2009 Mar;16(3):265-73
pubmed: 19234466
Cell. 2017 May 04;169(4):597-609.e11
pubmed: 28475892
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2083-90
pubmed: 22745174
Annu Rev Immunol. 2016 May 20;34:635-59
pubmed: 27168247
Cell. 2016 Apr 7;165(2):449-63
pubmed: 26949186
J Autoimmun. 2017 Sep;83:12-21
pubmed: 28479213
Immunity. 2018 Aug 21;49(2):301-311.e5
pubmed: 30076101
Cell. 2018 Jun 14;173(7):1783-1795.e14
pubmed: 29731169
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7
pubmed: 20876137
Elife. 2018 Nov 07;7:
pubmed: 30403372
Proc Natl Acad Sci U S A. 2018 May 1;115(18):4743-4748
pubmed: 29666227
Immunity. 2016 Nov 15;45(5):1108-1121
pubmed: 27851912
J Immunol Methods. 2008 Jan 1;329(1-2):112-24
pubmed: 17996249
J Exp Med. 2017 Jan;214(1):3-16
pubmed: 28003309
Retrovirology. 2018 Sep 5;15(1):61
pubmed: 30185183
Methods Mol Biol. 2009;504:351-83
pubmed: 19159106
Science. 2011 Sep 16;333(6049):1633-7
pubmed: 21764753
CSH Protoc. 2008 Mar 01;2008:pdb.prot4976
pubmed: 21356792
J Virol. 2001 Jun;75(12):5526-40
pubmed: 11356960
Immunity. 2018 Apr 17;48(4):799-811.e9
pubmed: 29669253
J Virol. 2011 Oct;85(19):9998-10009
pubmed: 21795340
Expert Rev Vaccines. 2016;15(3):349-65
pubmed: 26654478
Nat Med. 2015 Sep;21(9):1065-70
pubmed: 26301691
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
J Mol Biol. 2013 Apr 26;425(8):1302-17
pubmed: 23274142
J Virol. 2009 Jan;83(2):540-51
pubmed: 19004960
J Clin Invest. 2010 May;120(5):1663-73
pubmed: 20389023
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
J Exp Med. 2019 Oct 7;216(10):2331-2347
pubmed: 31345930
PLoS Pathog. 2011 Sep;7(9):e1002200
pubmed: 21909262
Immunity. 2018 Jan 16;48(1):133-146.e6
pubmed: 29287996
Science. 2011 Dec 2;334(6060):1289-93
pubmed: 22033520
Immunity. 2016 Sep 20;45(3):483-496
pubmed: 27617678
Immunity. 2018 May 15;48(5):855-871
pubmed: 29768174
PLoS One. 2011 Jan 26;6(1):e16074
pubmed: 21297864
Science. 2014 Dec 12;346(6215):1380-1383
pubmed: 25504724
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77
pubmed: 23115339
Front Microbiol. 2016 Oct 20;7:1667
pubmed: 27812357
J Virol. 2010 Oct;84(20):10700-7
pubmed: 20702640
Cell Host Microbe. 2016 Mar 9;19(3):292-303
pubmed: 26922989
Retrovirology. 2018 Nov 26;15(1):74
pubmed: 30477581
Immunol Rev. 2017 Jan;275(1):203-216
pubmed: 28133796
J Exp Med. 2013 Apr 8;210(4):655-63
pubmed: 23530120
Immunity. 2013 Aug 22;39(2):245-58
pubmed: 23911655
Science. 2015 Jul 10;349(6244):156-61
pubmed: 26089355
Nat Immunol. 2002 Jun;3(6):570-5
pubmed: 12021782
J Virol. 2010 Oct;84(20):10630-43
pubmed: 20702644
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298421
Science. 2010 Aug 13;329(5993):811-7
pubmed: 20616231
Nature. 2014 May 1;509(7498):55-62
pubmed: 24590074
Nat Commun. 2016 Feb 24;7:10618
pubmed: 26907590
Nat Med. 2018 Jun;24(6):857-867
pubmed: 29867235
Nat Struct Mol Biol. 2016 Jan;23(1):81-90
pubmed: 26689967
Cell. 2016 Sep 8;166(6):1445-1458.e12
pubmed: 27610569
J Mol Biol. 2017 Aug 18;429(17):2694-2709
pubmed: 28648617
Nat Med. 2015 Nov;21(11):1332-6
pubmed: 26457756
J Virol. 2014 Jan;88(1):699-704
pubmed: 24155380
J Virol. 2014 Mar;88(5):2645-57
pubmed: 24352455
Nature. 2013 Apr 25;496(7446):469-76
pubmed: 23552890
PLoS Pathog. 2013;9(11):e1003754
pubmed: 24278016
Immunol Rev. 2013 Jul;254(1):225-44
pubmed: 23772623
Immunol Rev. 2017 Jan;275(1):183-202
pubmed: 28133805
J Virol. 2001 Feb;75(3):1547-50
pubmed: 11152527