Dual Effect of

Animals Animals, Newborn Cell Cycle / physiology Cell Differentiation / physiology Cell Proliferation / physiology Diabetes Mellitus / genetics Insulin-Secreting Cells / cytology Mice Mice, Knockout Phosphorylation Regulatory-Associated Protein of mTOR / genetics Signal Transduction / physiology

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
10 2019
Historique:
received: 15 02 2019
accepted: 11 07 2019
pubmed: 28 7 2019
medline: 19 3 2020
entrez: 27 7 2019
Statut: ppublish

Résumé

Immature pancreatic β-cells are highly proliferative, and the expansion of β-cells during the early neonatal period largely determines functional β-cell mass; however, the mechanisms are poorly characterized. We generated Ngn3

Identifiants

DOI: 10.2337/db19-0166 PMID: 31345937
pubmed: 31345937
pii: db19-0166
doi: 10.2337/db19-0166
doi:

Substances chimiques

Regulatory-Associated Protein of mTOR 0
Rptor protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1950-1964

Informations de copyright

© 2019 by the American Diabetes Association.

Auteurs

Yanqiu Wang (Y)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jiajun Sun (J)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Qicheng Ni (Q)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aifang Nie (A)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Yanyun Gu (Y)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-4323-1648

Shu Wang (S)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Weizhen Zhang (W)

Department of Physiology and Pathophysiology, School of Basic Science, Peking University Health Science Center, Beijing, China.

Guang Ning (G)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China wqd11094@rjh.com.cn wqingw@hotmail.com guangning@medmail.com.cn.
ORCID: 0000-0002-5754-7635

Weiqing Wang (W)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China wqd11094@rjh.com.cn wqingw@hotmail.com guangning@medmail.com.cn.
ORCID: 0000-0001-6027-3084

Qidi Wang (Q)

Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China wqd11094@rjh.com.cn wqingw@hotmail.com guangning@medmail.com.cn.
Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ORCID: 0000-0003-3947-2761

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dual Effect of
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Dual Effect of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Dual Effect of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Dual Effect of
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Dual Effect of
questionsmedicales.fr › Maladies endocriniennes › Diabète › Dual Effect of
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Dual Effect of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dual Effect of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Dual Effect of
questionsmedicales.fr › Métabolisme › Phosphorylation › Dual Effect of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Protéine de régulation associée à mTOR › Dual Effect of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Dual Effect of