SLAMF9 regulates pDC homeostasis and function in health and disease.
Animals
Bone Marrow
/ metabolism
Cell Differentiation
Dendritic Cells
/ metabolism
Disease
Gene Expression Regulation
Health
Homeostasis
Lymph Nodes
/ metabolism
Lymphocyte Activation
/ immunology
Mice, Inbred C57BL
Mice, Knockout
Receptors, CCR5
/ metabolism
Signaling Lymphocytic Activation Molecule Family
/ deficiency
Transcriptome
/ genetics
EAE
SLAMF9
pDCs
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
pubmed:
28
7
2019
medline:
26
3
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
SLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, the role of SLAMF9 in the immune system remained mostly unexplored. By generating CRISPR/Cas9 SLAMF9 knockout mice, we analyzed the role of this receptor in plasmacytoid dendritic cells (pDCs), which preferentially express the SLAMF9 transcript and protein. These cells display a unique capacity to produce type I IFN and bridge between innate and adaptive immune response. Analysis of pDCs in SLAMF9
Identifiants
pubmed: 31346085
pii: 1900079116
doi: 10.1073/pnas.1900079116
pmc: PMC6697803
doi:
Substances chimiques
Receptors, CCR5
0
Signaling Lymphocytic Activation Molecule Family
0
Slamf9 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16489-16496Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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