Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil.
Journal
Medical science monitor : international medical journal of experimental and clinical research
ISSN: 1643-3750
Titre abrégé: Med Sci Monit
Pays: United States
ID NLM: 9609063
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
15
2
2020
Statut:
epublish
Résumé
<strong>BACKGROUND</strong> The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil. <strong>MATERIAL AND METHODS</strong> A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the polymorphism of ABCB1 rs1045642 using the TaqMan-MGB probe, and they were divided into 3 groups - a genotype AA group, a genotype AG group, and a genotype GG group - based on different genotypes of ABCB1 rs1045642. <strong>RESULTS</strong> The comparisons showed that there were no differences in sex, age, body mass index (BMI), smoking, drinking status, or ASA class among the 3 groups (
Identifiants
pubmed: 31346154
pii: 914921
doi: 10.12659/MSM.914921
pmc: PMC6647927
doi:
Substances chimiques
ABCB1 protein, human
0
ATP Binding Cassette Transporter, Subfamily B
0
Biomarkers, Pharmacological
0
Nucleoside Transport Proteins
0
adenosine transporter
0
Remifentanil
P10582JYYK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5258-5262Références
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