Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses.
CST9
Kininogen-1
MALDI-TOF/MS
Protein biomarker
Schizophrenia
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
03
2019
accepted:
19
06
2019
entrez:
27
7
2019
pubmed:
28
7
2019
medline:
28
7
2019
Statut:
epublish
Résumé
Schizophrenia (SCZ) is a complex and severe mental illness. There is a lack of effective biomarkers for SCZ diagnosis. The aim of this study was to explore the possibility of using serum peptides for the diagnosis of SCZ as well as analyze the association of variants in genes coding for these peptides and SCZ. After bead-based fractionation, the matrix-assisted laser desorption ionization/time-of-flight mass spectrometry technique was used to identify peptides that showed different expressions between 166 SCZ patients and 201 healthy controls. Differentially expressed peptides were verified in a second set of samples (81 SCZ patients and 103 healthy controls). The association of SCZ and three tagSNPs selected in genes coding for differentially expressed peptides was performed in 1,126 SCZ patients and 1,168 controls. The expression level of peptides with m/z 1,945.07 was significant lower in SCZ patients than in healthy controls ( The present study demonstrated that SCZ patients had decreased expression of Kininogen-1 and genetic variants in Kininogen-1 coding gene
Sections du résumé
BACKGROUND
BACKGROUND
Schizophrenia (SCZ) is a complex and severe mental illness. There is a lack of effective biomarkers for SCZ diagnosis. The aim of this study was to explore the possibility of using serum peptides for the diagnosis of SCZ as well as analyze the association of variants in genes coding for these peptides and SCZ.
METHODS
METHODS
After bead-based fractionation, the matrix-assisted laser desorption ionization/time-of-flight mass spectrometry technique was used to identify peptides that showed different expressions between 166 SCZ patients and 201 healthy controls. Differentially expressed peptides were verified in a second set of samples (81 SCZ patients and 103 healthy controls). The association of SCZ and three tagSNPs selected in genes coding for differentially expressed peptides was performed in 1,126 SCZ patients and 1,168 controls.
RESULTS
RESULTS
The expression level of peptides with m/z 1,945.07 was significant lower in SCZ patients than in healthy controls (
CONCLUSIONS
CONCLUSIONS
The present study demonstrated that SCZ patients had decreased expression of Kininogen-1 and genetic variants in Kininogen-1 coding gene
Identifiants
pubmed: 31346501
doi: 10.7717/peerj.7327
pii: 7327
pmc: PMC6642793
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e7327Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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