Clozapine and tardive dyskinesia in patients with schizophrenia: A systematic review.

Antipsychotic Agents / adverse effects Clozapine / pharmacology Dyskinesia, Drug-Induced / drug therapy Humans Schizophrenia / drug therapy
Schizophrenia antipsychotics clozapine extrapyramidal symptoms tardive dyskinesia

Journal

Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828

Informations de publication

Date de publication:
10 2019
Historique:
pubmed: 28 7 2019
medline: 18 8 2020
entrez: 27 7 2019
Statut: ppublish

Résumé

It is commonly recommended that a switch to clozapine be implemented in the face of tardive dyskinesia, even if current treatment involves another "atypical" agent. However, reports do indicate clozapine carries a liability for tardive dyskinesia. This review sought to evaluate clozapine in relation to tardive dyskinesia in the context of available evidence. Medline, Embase, and PsycINFO databases were searched for studies published in English, using the keywords: In total, 513 unique citations were identified and 29 reports met the inclusion criteria. Thirteen studies suggest clozapine reduces dyskinetic symptoms over time ( Research to date supports switching to clozapine for the purpose of reducing tardive dyskinesia risk and/or treating existing tardive dyskinesia, but prospective randomized controlled trials are necessary if we are to substantiate existing recommendations.

Sections du résumé

BACKGROUND
It is commonly recommended that a switch to clozapine be implemented in the face of tardive dyskinesia, even if current treatment involves another "atypical" agent. However, reports do indicate clozapine carries a liability for tardive dyskinesia.
AIMS
This review sought to evaluate clozapine in relation to tardive dyskinesia in the context of available evidence.
METHODS
Medline, Embase, and PsycINFO databases were searched for studies published in English, using the keywords:
RESULTS
In total, 513 unique citations were identified and 29 reports met the inclusion criteria. Thirteen studies suggest clozapine reduces dyskinetic symptoms over time (
CONCLUSIONS
Research to date supports switching to clozapine for the purpose of reducing tardive dyskinesia risk and/or treating existing tardive dyskinesia, but prospective randomized controlled trials are necessary if we are to substantiate existing recommendations.

Identifiants

DOI: 10.1177/0269881119862535 PMID: 31347436
pubmed: 31347436
doi: 10.1177/0269881119862535
doi:

Substances chimiques

Antipsychotic Agents 0
Clozapine J60AR2IKIC

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1187-1198

Auteurs

Parnian Pardis (P)

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-6405-4185

Gary Remington (G)

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Roshni Panda (R)

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Milan Lemez (M)

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Ofer Agid (O)

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Clozapine and tardive dyskinesia in patients...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Clozapine › Clozapine and tardive dyskinesia in patients...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Syndromes neurotoxiques › Dyskinésie due aux médicaments › Clozapine and tardive dyskinesia in patients...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clozapine and tardive dyskinesia in patients...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Clozapine and tardive dyskinesia in patients...