Alteration of testicular regulatory and functional molecules following long-time exposure to 900 MHz RFW emitted from BTS.
Animals
Cell Phone
Cholesterol Side-Chain Cleavage Enzyme
/ analysis
Dose-Response Relationship, Radiation
Down-Regulation
Environmental Exposure
/ adverse effects
Leydig Cells
/ metabolism
Male
Models, Animal
Phosphoproteins
/ analysis
Radio Waves
/ adverse effects
Rats
Rats, Sprague-Dawley
Reproduction
/ radiation effects
Testosterone
/ analysis
Time Factors
900 MHz radio frequency
P450scc
StAR
cytokine
testosterone
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
13
04
2019
revised:
12
06
2019
accepted:
21
06
2019
pubmed:
28
7
2019
medline:
15
2
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
The aim of this investigation was to evaluate changes in testosterone and some of the functional and regulatory molecules of testis such as P450scc, steroidogenic acute regulatory protein (StAR), tumour necrosis factor-α (TNF-α), interleukin-1α (IL-1α), interleukin-1β (IL-1β) and nerve growth factor (NGF) following exposure to 900 MHz radio frequency (RF). Thirty adult male Sprague Dawley rats (190 ± 20 g BW) were randomly classified in three equal groups, control (sham, without any exposure), short-time exposure (2 hr) (STE) and long-time exposure (4 hr) (LTE). The exposure was performed for 30 consecutive days. The testosterone level in both exposed groups was significantly less than control (p < .05). Level of TNF-α in both exposed groups was significantly greater than control (p < .05). IL-1α and NGF levels in LTE were significantly higher than the STE and control groups (p < .05). Level of IL-1β in LTE was significantly higher than control (p < .05). Expression of both P450scc and StAR mRNA was significantly down-regulated in both exposed groups compared to control (p < .05). Our results showed that RFW can affect testis and reproductive function through changes in factors, which are important during steroidogenesis, and also through changes in inflammatory factors, which regulate Leydig cell functions.
Substances chimiques
Phosphoproteins
0
steroidogenic acute regulatory protein
0
Testosterone
3XMK78S47O
Cholesterol Side-Chain Cleavage Enzyme
EC 1.14.15.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13372Subventions
Organisme : Shiraz University of Vice Chancellor of Research Affairs
Informations de copyright
© 2019 Blackwell Verlag GmbH.
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