Patterned functional network disruption in amyotrophic lateral sclerosis.
Adult
Aged
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Beta Rhythm
Brain Mapping
Cerebral Cortex
/ diagnostic imaging
Cognition
Delta Rhythm
Electroencephalography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
/ diagnostic imaging
Neuropsychological Tests
Psychomotor Performance
Theta Rhythm
EEG
amyotrophic lateral sclerosis
functional connectivity
motor neurone disease
resting state
source localisation
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
26
03
2019
revised:
01
07
2019
accepted:
17
07
2019
pubmed:
28
7
2019
medline:
15
4
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily affecting motor function, with additional evidence of extensive nonmotor involvement. Despite increasing recognition of the disease as a multisystem network disorder characterised by impaired connectivity, the precise neuroelectric characteristics of impaired cortical communication remain to be fully elucidated. Here, we characterise changes in functional connectivity using beamformer source analysis on resting-state electroencephalography recordings from 74 ALS patients and 47 age-matched healthy controls. Spatiospectral characteristics of network changes in the ALS patient group were quantified by spectral power, amplitude envelope correlation (co-modulation) and imaginary coherence (synchrony). We show patterns of decreased spectral power in the occipital and temporal (δ- to β-band), lateral/orbitofrontal (δ- to θ-band) and sensorimotor (β-band) regions of the brain in patients with ALS. Furthermore, we show increased co-modulation of neural oscillations in the central and posterior (δ-, θ- and γ
Identifiants
pubmed: 31348605
doi: 10.1002/hbm.24740
pmc: PMC6852475
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4827-4842Subventions
Organisme : Health Research Board of Ireland
ID : HRA-POR-2013-246
Pays : International
Organisme : Irish Institute of Clinical Neuroscience (IICN)-Novartis Ireland Research Grant
Pays : International
Organisme : Irish Research Council (Government of Ireland Postdoctoral Research Fellowship
ID : GOIPD/2015/213
Pays : International
Organisme : Irish Motor Neurone Disease Research Foundation
Pays : International
Organisme : Health Research Board of Ireland
ID : 16/ERCD/3854
Pays : International
Organisme : Perrigo Clinician-Scientist Research Fellowship
Pays : International
Organisme : Iris O'Brien Foundation
Pays : International
Organisme : Government of Ireland Postgraduate Scholarship
ID : GOIPG/2017/1014
Pays : International
Organisme : German Collaborative Research
ID : DFG-CRC-1193
Pays : International
Organisme : German Collaborative Research
ID : CRC-TR-128
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Science Foundation Ireland
Pays : Ireland
Organisme : Health Research Board of Ireland
ID : MRCG-2018-02
Pays : International
Organisme : Health Research Board of Ireland
ID : HRB-EIA-2017-019
Pays : International
Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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