Self-Assembling Peptide Hydrogel Matrices Improve the Neurotrophic Potential of Human Adipose-Derived Stem Cells.
Action Potentials
/ drug effects
Adipose Tissue
/ cytology
Animals
Cell Differentiation
/ drug effects
Cell Survival
/ drug effects
Cells, Cultured
Extracellular Matrix
/ metabolism
Female
Ganglia, Spinal
/ cytology
Gene Expression Regulation
/ drug effects
Humans
Hydrogels
/ pharmacology
Male
Nanofibers
/ ultrastructure
Nerve Regeneration
/ drug effects
Neurites
/ drug effects
Neuroglia
/ cytology
Peptides
/ pharmacology
Rats, Sprague-Dawley
Stem Cells
/ cytology
bioengineered nerve grafts
cell-biomaterial interactions
peripheral nerve regeneration
self-assembling peptide hydrogels
stem cell therapy
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
28
03
2019
revised:
09
07
2019
pubmed:
28
7
2019
medline:
28
8
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Despite advances in microsurgical techniques, treatment options to restore prior function following peripheral nerve injury remain unavailable, and autologous nerve grafting remains the therapy of choice. Recent experimental work has focused on the development of artificial constructs incorporating smart biomaterials and stem cells, aspiring to match/improve the outcomes of nerve autografting. Chemically stimulated human adipose-derived stem cells (dhASC) can improve nerve regeneration outcomes; however, these properties are lost when chemical stimulation is withdrawn, and survival rate upon transplantation is low. It is hypothesized that interactions with synthetic hydrogel matrices could maintain and improve neurotrophic characteristics of dhASC. dhASC are cultured on PeptiGel-Alpha 1 and PeptiGel-Alpha 2 self-assembling peptide hydrogels, showing comparable viability to collagen I control gels. Culturing dhASC on Alpha 1 and Alpha 2 substrates allow the maintenance of neurotrophic features, such as the expression of growth factors and neuroglial markers. Both Alpha 1 and Alpha 2 substrates are suitable for the culture of peripheral sensory neurons, permitting sprouting of neuronal extensions without the need of biological extracellular matrices, and preserving neuronal function. PeptiGel substrates loaded with hdASC are proposed as promising candidates for the development of tissue engineering therapies for the repair of peripheral nerve injuries.
Identifiants
pubmed: 31348622
doi: 10.1002/adhm.201900410
doi:
Substances chimiques
Hydrogels
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900410Subventions
Organisme : Manchester Regenerative Medicine Network (MaRMN)
Pays : International
Organisme : Department of Health
ID : II-LA-0313-20003
Pays : United Kingdom
Organisme : Engineering and Physical Sciences Research Council
ID : EP/K016210/1
Pays : International
Organisme : Academy of Medical Sciences
Pays : United Kingdom
Organisme : Hargreaves and Ball Trust
Pays : International
Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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