The cerebellum under stress.
Anticipation
Anxiety
Cerebellum
Depression
Post-traumatic stress disorder
Prediction
Stress
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
14
03
2019
revised:
19
07
2019
accepted:
20
07
2019
pubmed:
28
7
2019
medline:
3
3
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Stress-related psychiatric conditions are one of the main causes of disability in developed countries. They account for a large portion of resource investment in stress-related disorders, become chronic, and remain difficult to treat. Research on the neurobehavioral effects of stress reveals how changes in certain brain areas, mediated by a number of neurochemical messengers, markedly alter behavior. The cerebellum is connected with stress-related brain areas and expresses the machinery required to process stress-related neurochemical mediators. Surprisingly, it is not regarded as a substrate of stress-related behavioral alterations, despite numerous studies that show cerebellar responsivity to stress. Therefore, this review compiles those studies and proposes a hypothesis for cerebellar function in stressful conditions, relating it to stress-induced psychopathologies. It aims to provide a clearer picture of stress-related neural circuitry and stimulate cerebellum-stress research. Consequently, it might contribute to the development of improved treatment strategies for stress-related disorders.
Identifiants
pubmed: 31348932
pii: S0091-3022(19)30035-4
doi: 10.1016/j.yfrne.2019.100774
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100774Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.