"In vitro" behaviour of aptamer-functionalized polymeric nanocapsules loaded with 5-fluorouracil for targeted therapy.
5-fluorouracil
Aptamer-functionalized nanocapsules
Controlled drug release
Cytotoxicity
Hemocompatibility
Human breast carcinoma
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
15
01
2019
revised:
27
05
2019
accepted:
29
05
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
31
12
2019
Statut:
ppublish
Résumé
New type of nanocapsules based on carboxymethyl chitosan functionalized with AS1411 aptamer and poly(N-vinylpyrrolidone-alt-itaconic anhydride) loaded with 5-Fluorouracil (5-FU) were developed, with the potential to improve the treatment of cancer. Functionalization of nanocapsules with AS1411 aptamer will enhance their recognition by tumor cells, due to the interaction with nucleolin, and subsequent endocytosis. Nanocapsules were prepared by interfacial condensation method in the absence of any toxic crosslinking agents. The condensation reaction took place at the interface between the organic and aqueous phases by opening the anhydride cycles from the copolymer, under the action of the NH
Identifiants
pubmed: 31349496
pii: S0928-4931(19)30182-1
doi: 10.1016/j.msec.2019.109828
pii:
doi:
Substances chimiques
AGRO 100
0
Aptamers, Nucleotide
0
Delayed-Action Preparations
0
Nanocapsules
0
Oligodeoxyribonucleotides
0
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109828Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.