A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells.
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Breast
/ drug effects
Breast Neoplasms
/ drug therapy
Caspase Inhibitors
/ pharmacology
Caspases
/ metabolism
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Epithelial Cells
/ drug effects
Female
G2 Phase
/ drug effects
Histones
/ metabolism
Humans
MCF-7 Cells
Mitochondria
/ drug effects
Monoterpenes
/ pharmacology
Plocamium
/ chemistry
Rhodophyta
/ chemistry
Plocamium
apoptosis
cell cycle
chick chorioallantoic membrane assay
polyhalogenated monoterpenes
red algae
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
25 Jul 2019
25 Jul 2019
Historique:
received:
30
06
2019
revised:
17
07
2019
accepted:
23
07
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Breast cancer is the most common cancer type and a primary cause of cancer mortality among females worldwide. Here, we analyzed the anticancer efficacy of a novel bromochlorinated monoterpene, PPM1, a synthetic analogue of polyhalogenated monoterpenes from
Identifiants
pubmed: 31349625
pii: md17080437
doi: 10.3390/md17080437
pmc: PMC6723102
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Caspase Inhibitors
0
Histones
0
Monoterpenes
0
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Stae Ministry of Baden-Württemberg for Sciences, Research and Arts
ID : AZKIM
Références
Angew Chem Int Ed Engl. 2000 Oct 2;39(19):3430-3432
pubmed: 11091378
J Org Chem. 1997 Oct 17;62(21):7094-7095
pubmed: 11671809
Mol Cancer Ther. 2002 Jun;1(8):639-49
pubmed: 12479224
Cancer Metastasis Rev. 2003 Dec;22(4):451-64
pubmed: 12884918
J Med Chem. 1992 Aug 7;35(16):3007-11
pubmed: 1501227
Genes Dev. 2005 Feb 15;19(4):472-88
pubmed: 15681610
Infect Immun. 2005 Apr;73(4):1907-16
pubmed: 15784530
Phytochemistry. 2005 May;66(10):1108-12
pubmed: 15924916
J Nat Prod. 2006 Apr;69(4):576-9
pubmed: 16643029
J Immunol Methods. 1991 Jun 3;139(2):271-9
pubmed: 1710634
J Nat Prod. 2007 Apr;70(4):596-9
pubmed: 17343409
Z Naturforsch C. 2004 May-Jun;59(5-6):339-44
pubmed: 18998398
Phytochemistry. 2009 Mar;70(5):597-600
pubmed: 19345384
Annu Rev Genet. 2009;43:95-118
pubmed: 19659442
Nat Rev Clin Oncol. 2010 Dec;7(12):683-92
pubmed: 20877296
Mar Drugs. 2010 Aug 09;8(8):2301-17
pubmed: 20948909
Phytochemistry. 2011 Jun;72(8):769-72
pubmed: 21392811
Nat Rev Mol Cell Biol. 2011 Jun;12(6):385-92
pubmed: 21527953
J Clin Invest. 2011 Jul;121(7):2750-67
pubmed: 21633166
J Clin Oncol. 2011 Nov 20;29(33):4373-80
pubmed: 22010008
Breast Cancer Res Treat. 2012 Jun;133(3):917-28
pubmed: 22076480
Invest New Drugs. 2012 Dec;30(6):2187-200
pubmed: 22249429
J Biol Chem. 2012 Mar 23;287(13):9845-54
pubmed: 22311974
Development. 2013 Jan 1;140(1):3-12
pubmed: 23222436
Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12205-9
pubmed: 25220828
J Pharmacol Exp Ther. 2015 Jan;352(1):33-42
pubmed: 25316122
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
J Am Chem Soc. 2015 Oct 14;137(40):12784-7
pubmed: 26394844
Nat Methods. 2016 Jun;13(6):521-7
pubmed: 27135972
Nat Rev Clin Oncol. 2016 Nov;13(11):674-690
pubmed: 27184417
Nat Prod Res. 2017 Feb;31(3):261-267
pubmed: 27627578
Mar Drugs. 2017 Jul 20;15(7):null
pubmed: 28726723
Oncotarget. 2017 Jul 8;8(33):55147-55161
pubmed: 28903409
J Nat Prod. 2017 Dec 22;80(12):3203-3210
pubmed: 29190084
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Angew Chem Int Ed Engl. 1998 Aug 17;37(15):2085-2087
pubmed: 29711050
ESMO Open. 2018 May 3;3(Suppl 1):e000357
pubmed: 29765774
J Med Chem. 1994 Dec 9;37(25):4407-11
pubmed: 7996553
Cancer Chemother Pharmacol. 1996;39(1-2):51-60
pubmed: 8995499