Impact of HIV-1 Diversity on Its Sensitivity to Neutralization.
HIV-1 vaccine
broadly neutralizing antibodies
diversity
envelope
evolution
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
25 Jul 2019
25 Jul 2019
Historique:
received:
06
07
2019
revised:
22
07
2019
accepted:
23
07
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
28
7
2019
Statut:
epublish
Résumé
The HIV-1 pandemic remains a major burden on global public health and a vaccine to prevent HIV-1 infection is highly desirable but has not yet been developed. Among the many roadblocks to achieve this goal, the high antigenic diversity of the HIV-1 envelope protein (Env) is one of the most important and challenging to overcome. The recent development of broadly neutralizing antibodies has considerably improved our knowledge on Env structure and its interplay with neutralizing antibodies. This review aims at highlighting how the genetic diversity of HIV-1 thwarts current, and possibly future, vaccine developments. We will focus on the impact of HIV-1 Env diversification on the sensitivity to neutralizing antibodies and the repercussions of this continuous process at a population level.
Identifiants
pubmed: 31349655
pii: vaccines7030074
doi: 10.3390/vaccines7030074
pmc: PMC6789624
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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