Raw Cow's Milk Reduces Allergic Symptoms in a Murine Model for Food Allergy-A Potential Role For Epigenetic Modifications.
Acetylation
Animals
Cells, Cultured
Chromatin Assembly and Disassembly
Cytokines
/ immunology
Disease Models, Animal
Epigenesis, Genetic
Female
Food Hypersensitivity
/ diet therapy
Histones
/ metabolism
Immune Tolerance
Lymphocyte Activation
Mice, Inbred C3H
Milk
/ immunology
Ovalbumin
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Th1 Cells
/ immunology
Th2 Cells
/ immunology
epigenetics
farming effect
food allergy
histone acetylation
milk processing
raw milk
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
25 07 2019
25 07 2019
Historique:
received:
14
06
2019
revised:
22
07
2019
accepted:
23
07
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
21
1
2020
Statut:
epublish
Résumé
Epidemiological studies identified raw cow's milk consumption as an important environmental exposure that prevents allergic diseases. In the present study, we investigated whether raw cow's milk has the capacity to induce tolerance to an unrelated, non-milk, food allergen. Histone acetylation of T cell genes was investigated to assess potential epigenetic regulation. Female C3H/HeOuJ mice were sensitized and challenged to ovalbumin. Prior to sensitization, the mice were treated with raw milk, processed milk, or phosphate-buffered saline for eight days. Allergic symptoms were assessed after challenge and histone modifications in T cell-related genes of splenocyte-derived CD4
Identifiants
pubmed: 31349704
pii: nu11081721
doi: 10.3390/nu11081721
pmc: PMC6723026
pii:
doi:
Substances chimiques
Cytokines
0
Histones
0
Ovalbumin
9006-59-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
J.G. and B.C.A.M.v.E. are (partly) employed at Danone Nutricia Research. All other authors report no potential conflicts of interest.
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