Behavioral Disturbances in Dementia and Beyond: Time for a New Conceptual Frame?
Alzheimer’s disease
antipsychotics
behavioral disturbances clusters
mixed dementia
vascular dementia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Jul 2019
25 Jul 2019
Historique:
received:
28
05
2019
revised:
19
07
2019
accepted:
23
07
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
3
1
2020
Statut:
epublish
Résumé
Alzheimer's disease and vascular dementia are estimated to be the most common causes of dementia, although mixed dementia could represent the most prevalent form of dementia in older adults aged more than 80 years. Behavioral disturbances are common in the natural history of dementia. However, so far, there is a paucity of studies that investigated the causal association between behavioral psychological symptoms of dementia and dementia sub-types, due to the high heterogeneity of methodology, study design and type of clinical assessment. To understand the scant evidence on such a relevant clinical issue, it could be hypothesized that a new shifting paradigm could result in a better identification of the relationship between behavioral disturbances and dementia. This narrative review provides an update of evidence on the behavioral patterns associated with different dementia sub-types and offers a potential future perspective as common ground for the development of new translational studies in the field of behavioral disturbances in dementia and the appropriateness of psychoactive treatments.
Identifiants
pubmed: 31349706
pii: ijms20153647
doi: 10.3390/ijms20153647
pmc: PMC6695658
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
none to declare.
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