Irisin vs. Treadmill Exercise in Post Myocardial Infarction Cardiac Rehabilitation in Rats.
Cardiac rehabilitation
Cardiac remodeling
Dihydromyricetin
Exercise
Irisin
Myocardial infarction
Journal
Archives of medical research
ISSN: 1873-5487
Titre abrégé: Arch Med Res
Pays: United States
ID NLM: 9312706
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
06
02
2019
revised:
03
05
2019
accepted:
22
05
2019
entrez:
28
7
2019
pubmed:
28
7
2019
medline:
27
2
2020
Statut:
ppublish
Résumé
Irisin is an exercise-induced myokine that could play a role in post-myocardial infarction (MI) cardiac rehabilitation. We investigated the ability of dihydromyricetin to mimic the effects of exercise on raising serum irisin and on enhancing cardiac function and remodeling following MI in rats. MI was induced in albino rats by subcutaneous injection of isoproterenol (85 mg/kg) for 2 consecutive days at an interval of 24 h. One week post-MI, rats either underwent physical exercise by running on a motor-driven treadmill at 25 m/min, 30 min/d, 5 d/week or received orally dihydromyricetin 100 mg/kg/d, for 8 weeks. Exercise and dihydromyricetin raised serum irisin 1.8 and 1.9 folds as compared to sedentary rats (p <0.001) with no difference between both regimens (p = 0.992). There was an improvement of cardiac remodeling where β-myosin heavy chain level was not different in exercise and dihydromyricetin groups from normal group (p = 0.695, p = 0.470). The heart rate variability domains increased back to normal. However, exercise was superior to dihydromyricetin in improving cardiac contractility by increasing carotid blood flow, stroke volume and cardiac output to be insignificant from normal rats (p = 0.899, p = 0.850, p = 0.912). Meanwhile, treatment with dihydromyricetin showed reduction by 29% of carotid blood flow, 24% of stroke volume and 25% of cardiac output compared to normal rats (p <0.001). DHM could mimic the effect of exercise in stimulating irisin secretion but it is not as effective as exercise in improving myocardial contractility.
Sections du résumé
BACKGROUND
Irisin is an exercise-induced myokine that could play a role in post-myocardial infarction (MI) cardiac rehabilitation.
AIM OF THE STUDY
We investigated the ability of dihydromyricetin to mimic the effects of exercise on raising serum irisin and on enhancing cardiac function and remodeling following MI in rats.
METHODS
MI was induced in albino rats by subcutaneous injection of isoproterenol (85 mg/kg) for 2 consecutive days at an interval of 24 h. One week post-MI, rats either underwent physical exercise by running on a motor-driven treadmill at 25 m/min, 30 min/d, 5 d/week or received orally dihydromyricetin 100 mg/kg/d, for 8 weeks.
RESULTS
Exercise and dihydromyricetin raised serum irisin 1.8 and 1.9 folds as compared to sedentary rats (p <0.001) with no difference between both regimens (p = 0.992). There was an improvement of cardiac remodeling where β-myosin heavy chain level was not different in exercise and dihydromyricetin groups from normal group (p = 0.695, p = 0.470). The heart rate variability domains increased back to normal. However, exercise was superior to dihydromyricetin in improving cardiac contractility by increasing carotid blood flow, stroke volume and cardiac output to be insignificant from normal rats (p = 0.899, p = 0.850, p = 0.912). Meanwhile, treatment with dihydromyricetin showed reduction by 29% of carotid blood flow, 24% of stroke volume and 25% of cardiac output compared to normal rats (p <0.001).
CONCLUSIONS
DHM could mimic the effect of exercise in stimulating irisin secretion but it is not as effective as exercise in improving myocardial contractility.
Identifiants
pubmed: 31349953
pii: S0188-4409(19)30127-4
doi: 10.1016/j.arcmed.2019.05.009
pii:
doi:
Substances chimiques
FNDC5 protein, rat
0
Fibronectins
0
Flavonols
0
dihydromyricetin
KD8QND6427
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-54Informations de copyright
Copyright © 2019 IMSS. Published by Elsevier Inc. All rights reserved.