How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.
computational model
dendrites
dendritic dynamics
local translation
neuron
protein dynamics
synaptic plasticity
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
25 09 2019
25 09 2019
Historique:
received:
12
09
2018
revised:
21
02
2019
accepted:
22
06
2019
pubmed:
28
7
2019
medline:
25
3
2020
entrez:
28
7
2019
Statut:
ppublish
Résumé
Proteins drive the function of neuronal synapses. The synapses are distributed throughout the dendritic arbor, often hundreds of micrometers away from the soma. It is still unclear how somatic and dendritic sources of proteins shape protein distribution and respectively contribute to local protein changes during synaptic plasticity. Here, we present a unique computational framework describing for a given protein species the dendritic distribution of the mRNA and the corresponding protein in a dendrite. Using CaMKIIα as a test case, our model reveals the key role active transport plays in the maintenance of dendritic mRNA and protein levels and predicts the short and long timescales of protein dynamics. Our model reveals the fundamental role of mRNA localization and dendritic mRNA translation in synaptic maintenance and plasticity in distal compartments. We developed a web application for neuroscientists to explore the dynamics of the mRNA or protein of interest.
Identifiants
pubmed: 31350097
pii: S0896-6273(19)30572-0
doi: 10.1016/j.neuron.2019.06.022
pii:
doi:
Substances chimiques
RNA, Messenger
0
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Camk2a protein, rat
EC 2.7.11.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1109-1122.e7Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.