Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.

Animals Cellular Senescence Heterochromatin / genetics Humans Lamin Type B / genetics Male Mesenchymal Stem Cells / metabolism Mice Mice, Inbred C57BL Mice, Inbred NOD MicroRNAs / genetics Osteoarthritis / genetics Protein Stability RNA-Binding Proteins / genetics Tripartite Motif-Containing Protein 28 / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
26 07 2019
Historique:
received: 17 05 2018
accepted: 03 06 2019
entrez: 28 7 2019
pubmed: 28 7 2019
medline: 31 12 2019
Statut: epublish

Résumé

DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied. Here, we demonstrate that DGCR8 plays an important role in maintaining heterochromatin organization and attenuating aging. An N-terminal-truncated version of DGCR8 (DR8

Identifiants

DOI: 10.1038/s41467-019-10831-8 PMID: 31350386 PMC: PMC6659673
pubmed: 31350386
doi: 10.1038/s41467-019-10831-8
pii: 10.1038/s41467-019-10831-8
pmc: PMC6659673
doi:

Substances chimiques

DGCR8 protein, human 0
Dgcr8 protein, mouse 0
Heterochromatin 0
Lamin Type B 0
MicroRNAs 0
RNA-Binding Proteins 0
TRIM28 protein, human EC 2.3.2.27
Tripartite Motif-Containing Protein 28 EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3329

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Auteurs

Liping Deng (L)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.

Ruotong Ren (R)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

Zunpeng Liu (Z)

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.

Moshi Song (M)

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China.

Jingyi Li (J)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China.

Zeming Wu (Z)

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.

Xiaoqing Ren (X)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.

Lina Fu (L)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.

Wei Li (W)

Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China.

Weiqi Zhang (W)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China.
Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China.
Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, 100101, Beijing, China.

Pedro Guillen (P)

Clinica Cemtro. Av. del Ventisquero de la Condesa, 42, 28035, Madrid, Spain.

Juan Carlos Izpisua Belmonte (JC)

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.

Piu Chan (P)

Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China.

Jing Qu (J)

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China. qujing@ioz.ac.cn.
University of Chinese Academy of Sciences, 100049, Beijing, China. qujing@ioz.ac.cn.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China. qujing@ioz.ac.cn.

Guang-Hui Liu (GH)

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. ghliu@ibp.ac.cn.
University of Chinese Academy of Sciences, 100049, Beijing, China. ghliu@ibp.ac.cn.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101, Beijing, China. ghliu@ibp.ac.cn.
Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, 100053, Beijing, China. ghliu@ibp.ac.cn.
Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, 510632, Guangzhou, China. ghliu@ibp.ac.cn.
Beijing Institute for Brain Disorders, Capital Medical University, 100069, Beijing, China. ghliu@ibp.ac.cn.
ORCID: 0000-0001-9289-8177

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Hétérochromatine › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines associées à la matrice nucléaire › Lamines › Lamine B › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Stabilizing heterochromatin by DGCR8...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Protéine-28 à motif tripartite › Stabilizing heterochromatin by DGCR8...