Neutrophil-related Variables Have Different Prognostic Effect Based on Primary Tumor Location in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Biomarkers, Tumor
/ analysis
Colorectal Neoplasms
/ drug therapy
Female
Follow-Up Studies
Humans
Lymphocytes
/ pathology
Male
Middle Aged
Neoplasm Metastasis
Neutrophils
/ pathology
Prognosis
Retrospective Studies
Survival Rate
Chemotherapy
Colorectal cancer
Neutrophil
Prognosis
Systemic inflammation
Journal
Clinical colorectal cancer
ISSN: 1938-0674
Titre abrégé: Clin Colorectal Cancer
Pays: United States
ID NLM: 101120693
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
31
12
2018
revised:
02
06
2019
accepted:
25
06
2019
pubmed:
29
7
2019
medline:
24
7
2020
entrez:
29
7
2019
Statut:
ppublish
Résumé
Clinical data reported a relationship between neutrophil-related variables and poor prognosis in patients with metastatic colorectal cancer (mCRC), but only platelet-to-lymphocyte ratio has been reported as prognostic. A retrospective analysis of 145 patients with mCRC, who received chemotherapy at the department of Oncology of the Ospedale Civile di Sanremo in 2010 to 2013, was performed, and a Cox model was built. In the model, some variables were independently related with overall survival (OS) (resection of the primary tumor, number of drugs included in the first-line chemotherapy regimen), whereas neutrophil-related ones were not. However, after stratification by tumor location, neutrophil-related variables appeared associated with a poor survival among patients with a left-sided mCRC, and in particular, among those ones with a rectal tumor (hazard ratio, 3.732; 95% confidence interval, 1.575-8.845). Neutrophil-related variables predicted outcome in patients with left-sided mCRC only. A high prevalence of consensus molecular subtype 4 CRC in patients with metastatic cancer of the rectum is suggested.
Sections du résumé
BACKGROUND
Clinical data reported a relationship between neutrophil-related variables and poor prognosis in patients with metastatic colorectal cancer (mCRC), but only platelet-to-lymphocyte ratio has been reported as prognostic.
PATIENTS AND METHODS
A retrospective analysis of 145 patients with mCRC, who received chemotherapy at the department of Oncology of the Ospedale Civile di Sanremo in 2010 to 2013, was performed, and a Cox model was built.
RESULTS
In the model, some variables were independently related with overall survival (OS) (resection of the primary tumor, number of drugs included in the first-line chemotherapy regimen), whereas neutrophil-related ones were not. However, after stratification by tumor location, neutrophil-related variables appeared associated with a poor survival among patients with a left-sided mCRC, and in particular, among those ones with a rectal tumor (hazard ratio, 3.732; 95% confidence interval, 1.575-8.845).
CONCLUSION
Neutrophil-related variables predicted outcome in patients with left-sided mCRC only. A high prevalence of consensus molecular subtype 4 CRC in patients with metastatic cancer of the rectum is suggested.
Identifiants
pubmed: 31351861
pii: S1533-0028(18)30616-9
doi: 10.1016/j.clcc.2019.06.007
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e343-e348Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.